Changes in PKM2 Associate with Prostate Cancer Progression

Pyruvate kinase M2 (PKM2) is essential for aerobic glycolysis, the dominant metabolic pathway utilized by cancer cells. To determine the association of PKM2 with prostate cancer (PC), we examined 29 primary PC and three lymph node metastatic tumors; elevation of PKM2 was observed in Gleason 8-10 tum...

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Bibliographic Details
Published in:Cancer investigation 2014-08, Vol.32 (7), p.330-338
Main Authors: Wong, Nicholas, Yan, Judy, Ojo, Diane, De Melo, Jason, Cutz, Jean-Claude, Tang, Damu
Format: Article
Language:English
Subjects:
Aged
Animals
Cancer Metabolism
Carrier Proteins - genetics
Carrier Proteins - metabolism
Cell Line, Tumor
Cell Proliferation
Genetic Predisposition to Disease
Glycolysis - genetics
Humans
Lymphatic Metastasis
Male
Membrane Proteins - genetics
Membrane Proteins - metabolism
Mice
Mice, Inbred NOD
Mice, SCID
Middle Aged
Neoplasm Grading
Neoplasm Transplantation
PKM2
Prostate cancer
Prostatic Neoplasms - genetics
Prostatic Neoplasms - pathology
Protein Processing, Post-Translational
Thyroid Hormone-Binding Proteins
Thyroid Hormones - genetics
Thyroid Hormones - metabolism
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Summary:Pyruvate kinase M2 (PKM2) is essential for aerobic glycolysis, the dominant metabolic pathway utilized by cancer cells. To determine the association of PKM2 with prostate cancer (PC), we examined 29 primary PC and three lymph node metastatic tumors; elevation of PKM2 was observed in Gleason 8-10 tumors compared to Gleason 6-7 carcinomas. High PKM2 was detected by immunohistochemistry in more aggressive xenograft tumors derived from PC stem-like cells (PCSCs) compared to those produced from non-PCSCs. While PCSCs and non-PCSCs expressed comparable levels of PKM2, distinct posttranslational modifications were observed. Collectively, upregulation and specific modification to PKM2 associate with PC progression.
ISSN:0735-7907
1532-4192
DOI:10.3109/07357907.2014.919306