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Changes in PKM2 Associate with Prostate Cancer Progression
Pyruvate kinase M2 (PKM2) is essential for aerobic glycolysis, the dominant metabolic pathway utilized by cancer cells. To determine the association of PKM2 with prostate cancer (PC), we examined 29 primary PC and three lymph node metastatic tumors; elevation of PKM2 was observed in Gleason 8-10 tum...
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| Published in: | Cancer investigation 2014-08, Vol.32 (7), p.330-338 |
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| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c418t-c61e907c6d75fa7d8c78929901dd3031d6d2390376444bcc3dcf4e11151a83683 |
| container_end_page | 338 |
| container_issue | 7 |
| container_start_page | 330 |
| container_title | Cancer investigation |
| container_volume | 32 |
| creator | Wong, Nicholas Yan, Judy Ojo, Diane De Melo, Jason Cutz, Jean-Claude Tang, Damu |
| description | Pyruvate kinase M2 (PKM2) is essential for aerobic glycolysis, the dominant metabolic pathway utilized by cancer cells. To determine the association of PKM2 with prostate cancer (PC), we examined 29 primary PC and three lymph node metastatic tumors; elevation of PKM2 was observed in Gleason 8-10 tumors compared to Gleason 6-7 carcinomas. High PKM2 was detected by immunohistochemistry in more aggressive xenograft tumors derived from PC stem-like cells (PCSCs) compared to those produced from non-PCSCs. While PCSCs and non-PCSCs expressed comparable levels of PKM2, distinct posttranslational modifications were observed. Collectively, upregulation and specific modification to PKM2 associate with PC progression. |
| doi_str_mv | 10.3109/07357907.2014.919306 |
| format | article |
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To determine the association of PKM2 with prostate cancer (PC), we examined 29 primary PC and three lymph node metastatic tumors; elevation of PKM2 was observed in Gleason 8-10 tumors compared to Gleason 6-7 carcinomas. High PKM2 was detected by immunohistochemistry in more aggressive xenograft tumors derived from PC stem-like cells (PCSCs) compared to those produced from non-PCSCs. While PCSCs and non-PCSCs expressed comparable levels of PKM2, distinct posttranslational modifications were observed. Collectively, upregulation and specific modification to PKM2 associate with PC progression.</description><identifier>ISSN: 0735-7907</identifier><identifier>EISSN: 1532-4192</identifier><identifier>DOI: 10.3109/07357907.2014.919306</identifier><identifier>PMID: 24884829</identifier><language>eng</language><publisher>England: Informa Healthcare</publisher><subject>Aged ; Animals ; Cancer Metabolism ; Carrier Proteins - genetics ; Carrier Proteins - metabolism ; Cell Line, Tumor ; Cell Proliferation ; Genetic Predisposition to Disease ; Glycolysis - genetics ; Humans ; Lymphatic Metastasis ; Male ; Membrane Proteins - genetics ; Membrane Proteins - metabolism ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Middle Aged ; Neoplasm Grading ; Neoplasm Transplantation ; PKM2 ; Prostate cancer ; Prostatic Neoplasms - genetics ; Prostatic Neoplasms - pathology ; Protein Processing, Post-Translational ; Thyroid Hormone-Binding Proteins ; Thyroid Hormones - genetics ; Thyroid Hormones - metabolism</subject><ispartof>Cancer investigation, 2014-08, Vol.32 (7), p.330-338</ispartof><rights>2014 Informa Healthcare USA, Inc. 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-c61e907c6d75fa7d8c78929901dd3031d6d2390376444bcc3dcf4e11151a83683</citedby><cites>FETCH-LOGICAL-c418t-c61e907c6d75fa7d8c78929901dd3031d6d2390376444bcc3dcf4e11151a83683</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24884829$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wong, Nicholas</creatorcontrib><creatorcontrib>Yan, Judy</creatorcontrib><creatorcontrib>Ojo, Diane</creatorcontrib><creatorcontrib>De Melo, Jason</creatorcontrib><creatorcontrib>Cutz, Jean-Claude</creatorcontrib><creatorcontrib>Tang, Damu</creatorcontrib><title>Changes in PKM2 Associate with Prostate Cancer Progression</title><title>Cancer investigation</title><addtitle>Cancer Invest</addtitle><description>Pyruvate kinase M2 (PKM2) is essential for aerobic glycolysis, the dominant metabolic pathway utilized by cancer cells. To determine the association of PKM2 with prostate cancer (PC), we examined 29 primary PC and three lymph node metastatic tumors; elevation of PKM2 was observed in Gleason 8-10 tumors compared to Gleason 6-7 carcinomas. High PKM2 was detected by immunohistochemistry in more aggressive xenograft tumors derived from PC stem-like cells (PCSCs) compared to those produced from non-PCSCs. While PCSCs and non-PCSCs expressed comparable levels of PKM2, distinct posttranslational modifications were observed. Collectively, upregulation and specific modification to PKM2 associate with PC progression.</description><subject>Aged</subject><subject>Animals</subject><subject>Cancer Metabolism</subject><subject>Carrier Proteins - genetics</subject><subject>Carrier Proteins - metabolism</subject><subject>Cell Line, Tumor</subject><subject>Cell Proliferation</subject><subject>Genetic Predisposition to Disease</subject><subject>Glycolysis - genetics</subject><subject>Humans</subject><subject>Lymphatic Metastasis</subject><subject>Male</subject><subject>Membrane Proteins - genetics</subject><subject>Membrane Proteins - metabolism</subject><subject>Mice</subject><subject>Mice, Inbred NOD</subject><subject>Mice, SCID</subject><subject>Middle Aged</subject><subject>Neoplasm Grading</subject><subject>Neoplasm Transplantation</subject><subject>PKM2</subject><subject>Prostate cancer</subject><subject>Prostatic Neoplasms - genetics</subject><subject>Prostatic Neoplasms - pathology</subject><subject>Protein Processing, Post-Translational</subject><subject>Thyroid Hormone-Binding Proteins</subject><subject>Thyroid Hormones - genetics</subject><subject>Thyroid Hormones - metabolism</subject><issn>0735-7907</issn><issn>1532-4192</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNp9kE1LAzEQhoMoWj_-gcgevWzNJNlN4kEpi19YsQc9hzTJtivbTU22lP57d2kVvPQ0DDzzzsuD0CXgIQUsbzCnGZeYDwkGNpQgKc4P0AAySlIGkhyiQY-kPXOCTmP8whgE4dkxOiFMCCaIHKDbYq6bmYtJ1SST1zeSjGL0ptKtS9ZVO08mwce23wrdGBf6fRZcjJVvztFRqevoLnbzDH0-PnwUz-n4_emlGI1Tw0C0qcnBdRVMbnlWam6F4UISKTFYSzEFm1tCJaY8Z4xNjaHWlMwBQAZa0FzQM3S9zV0G_71ysVWLKhpX17pxfhUVZIxRwjKedSjboqarHYMr1TJUCx02CrDqralfa6q3prbWurOr3YfVdOHs39Gvpg643wJVU_qw0Gsfaqtaval9KENnpop9_N4Xd_8S5k7X7dzo4NSXX4WmE7i_4w9aLozW</recordid><startdate>20140809</startdate><enddate>20140809</enddate><creator>Wong, Nicholas</creator><creator>Yan, Judy</creator><creator>Ojo, Diane</creator><creator>De Melo, Jason</creator><creator>Cutz, Jean-Claude</creator><creator>Tang, Damu</creator><general>Informa Healthcare</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140809</creationdate><title>Changes in PKM2 Associate with Prostate Cancer Progression</title><author>Wong, Nicholas ; 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To determine the association of PKM2 with prostate cancer (PC), we examined 29 primary PC and three lymph node metastatic tumors; elevation of PKM2 was observed in Gleason 8-10 tumors compared to Gleason 6-7 carcinomas. High PKM2 was detected by immunohistochemistry in more aggressive xenograft tumors derived from PC stem-like cells (PCSCs) compared to those produced from non-PCSCs. While PCSCs and non-PCSCs expressed comparable levels of PKM2, distinct posttranslational modifications were observed. Collectively, upregulation and specific modification to PKM2 associate with PC progression.</abstract><cop>England</cop><pub>Informa Healthcare</pub><pmid>24884829</pmid><doi>10.3109/07357907.2014.919306</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0735-7907 |
| ispartof | Cancer investigation, 2014-08, Vol.32 (7), p.330-338 |
| issn | 0735-7907 1532-4192 |
| language | eng |
| recordid | cdi_pubmed_primary_24884829 |
| source | Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list) |
| subjects | Aged Animals Cancer Metabolism Carrier Proteins - genetics Carrier Proteins - metabolism Cell Line, Tumor Cell Proliferation Genetic Predisposition to Disease Glycolysis - genetics Humans Lymphatic Metastasis Male Membrane Proteins - genetics Membrane Proteins - metabolism Mice Mice, Inbred NOD Mice, SCID Middle Aged Neoplasm Grading Neoplasm Transplantation PKM2 Prostate cancer Prostatic Neoplasms - genetics Prostatic Neoplasms - pathology Protein Processing, Post-Translational Thyroid Hormone-Binding Proteins Thyroid Hormones - genetics Thyroid Hormones - metabolism |
| title | Changes in PKM2 Associate with Prostate Cancer Progression |
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