Intercellular Adhesion Molecule-1 K469E and Angiotensinogen T207M Polymorphisms in Coronary Slow Flow

Objective: To investigate intercellular adhesion molecule-1 (ICAM1) and angiotensinogen (AGT) gene polymorphisms, as related to atherosclerosis and endothelial dysfunction, in coronary slow flow (CSF). Subjects and Methods: The participants in this study were 48 patients with CSF and 67 patients wit...

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Bibliographic Details
Published in:Medical principles and practice 2014-01, Vol.23 (4), p.346-350
Main Authors: Gazi, Emine, Barutcu, Ahmet, Altun, Burak, Temiz, Ahmet, Bekler, Adem, Urfali, Mine, Silan, Fatma, Colkesen, Yucel, Ozdemir, Ozturk
Format: Article
Language:English
Subjects:
Aged
Angiotensinogen - genetics
Coronary Artery Disease - genetics
Coronary Artery Disease - physiopathology
Coronary Circulation - genetics
Coronary Vessels - physiopathology
Endothelium, Vascular - physiopathology
Female
Genotype
Humans
Intercellular Adhesion Molecule-1 - genetics
Male
Middle Aged
Original Paper
Polymorphism, Genetic
Risk Factors
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Summary:Objective: To investigate intercellular adhesion molecule-1 (ICAM1) and angiotensinogen (AGT) gene polymorphisms, as related to atherosclerosis and endothelial dysfunction, in coronary slow flow (CSF). Subjects and Methods: The participants in this study were 48 patients with CSF and 67 patients with normal coronary flow as controls. The K469E polymorphism of ICAM1 (rs5498) and the T207M polymorphism of AGT (rs4762) were determined using the polymerase chain reaction amplification method. Results: Baseline demographic parameters were similar in both groups. The mean thrombolysis in myocardial infarction frame count was significantly higher in patients with CSF (23.8 ± 5.1) compared to the controls (13.3 ± 2.6, p < 0.001). A significant association was found between the ICAM1 K allele and CSF (OR: 1.96, 95% CI: 1.15-3.35, p = 0.013). There was no difference in the frequency of AGT T207M genotypes in the patients with CSF and the control subjects. Conclusion: This study showed that K469E polymorphisms of ICAM1 that play a role in atherosclerotic pathogenesis are related to CSF.
ISSN:1011-7571
1423-0151
DOI:10.1159/000363451