Androgen receptor enhances cell adhesion and decreases cell migration via modulating β1-integrin-AKT signaling in hepatocellular carcinoma cells

Highlights • This paper explained in cellular level why AR promotes cancer growth, and suppresses metastasis. • AR signal promote cell focal adhesion through β1-integrin expression. • AR signal suppress cell migration also through β1-integrin expression. • The AR-β1-integrin pathway could enhance ac...

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Bibliographic Details
Published in:Cancer letters 2014-08, Vol.351 (1), p.64-71
Main Authors: Ma, Wen-Lung, Jeng, Long-Bin, Lai, Hsueh-Chou, Liao, Pei-Yin, Chang, Chawnshang
Format: Article
Language:English
Subjects:
Adhesion
Androgen receptor
Animals
Apoptosis
Carcinoma, Hepatocellular - chemically induced
Carcinoma, Hepatocellular - metabolism
Carcinoma, Hepatocellular - pathology
Cell Adhesion
Cell Line, Tumor
Cell Movement
Diethylnitrosamine
Female
Gene Expression
HEK293 Cells
Hematology, Oncology and Palliative Medicine
Hepatocellular carcinoma
Humans
Integrin alphaV - genetics
Integrin alphaV - metabolism
Integrin beta1 - genetics
Integrin beta1 - metabolism
Liver Neoplasms, Experimental - chemically induced
Liver Neoplasms, Experimental - metabolism
Liver Neoplasms, Experimental - pathology
Male
Mice
Mice, Transgenic
Migration
Proto-Oncogene Proteins c-akt - metabolism
Receptors, Androgen - physiology
Signal Transduction
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Summary:Highlights • This paper explained in cellular level why AR promotes cancer growth, and suppresses metastasis. • AR signal promote cell focal adhesion through β1-integrin expression. • AR signal suppress cell migration also through β1-integrin expression. • The AR-β1-integrin pathway could enhance activation of PI3K/AKT signaling.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2014.05.017