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A Bayesian Estimation Framework for Pharmacogenomics Driven Warfarin Dosing: A Comparative Study

The incorporation of pharmacogenomics information into the drug dosing estimation formulations has been shown to increase the accuracy in drug dosing and decrease the frequency of adverse drug effects in many studies in the literature. In this paper, an estimation framework based on the Bayesian str...

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Published in:	IEEE journal of biomedical and health informatics 2015-09, Vol.19 (5), p.1724-1733
Main Authors:	Oztaner, Serdar Murat, Temizel, Tugba Taskaya, Erdem, S. Remzi, Ozer, Mahmut
Format:	Article
Language:	English
Subjects:	Adolescent Adult Aged Aged, 80 and over Analytical models Bayes methods Bayes Theorem Child Cohort Studies Cytochrome P-450 CYP2C9 - genetics Data Mining Data models Databases, Factual Equations Estimation Humans Informatics Mathematical model Middle Aged Pharmacogenetics - methods Precision Medicine - methods Turkey Vitamin K Epoxide Reductases - genetics Warfarin - administration & dosage Warfarin - pharmacology Whites - genetics Young Adult
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creator	Oztaner, Serdar Murat Temizel, Tugba Taskaya Erdem, S. Remzi Ozer, Mahmut
description	The incorporation of pharmacogenomics information into the drug dosing estimation formulations has been shown to increase the accuracy in drug dosing and decrease the frequency of adverse drug effects in many studies in the literature. In this paper, an estimation framework based on the Bayesian structural equation modeling, which is driven by pharmacogenomics, is proposed. The results show that the model compares favorably with the linear models in terms of prediction and explaining the variations in warfarin dosing.
doi_str_mv	10.1109/JBHI.2014.2336974
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subjects	Adolescent Adult Aged Aged, 80 and over Analytical models Bayes methods Bayes Theorem Child Cohort Studies Cytochrome P-450 CYP2C9 - genetics Data Mining Data models Databases, Factual Equations Estimation Humans Informatics Mathematical model Middle Aged Pharmacogenetics - methods Precision Medicine - methods Turkey Vitamin K Epoxide Reductases - genetics Warfarin - administration & dosage Warfarin - pharmacology Whites - genetics Young Adult
title	A Bayesian Estimation Framework for Pharmacogenomics Driven Warfarin Dosing: A Comparative Study
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