Inhibitor screening of lactate dehydrogenase C4 from black-lipped pika in the Western Sichuan Plateau

Studies indicated that lactate dehydrogenase C4 (LDH-C4) was a good target protein for development of contraceptive drugs. Virtual screening and in vitro enzyme assay using pika LDH-C4 as target protein revealed NSC61610, NSC215718, and NSC345647 with K i of 7.8, 27, and 41 μM separately. This study...

Full description

Saved in:
Bibliographic Details
Published in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2014, Vol.78 (4), p.651-654
Main Authors: Zhang, Qinglian, He, Qinghua, Xue, Fulai, Ma, Jinhu
Format: Article
Language:English
Subjects:
Animals
Catalytic Domain
China
Drug Evaluation, Preclinical
Enzyme Inhibitors - metabolism
Enzyme Inhibitors - pharmacology
inhibitor
Isoenzymes - antagonists & inhibitors
Isoenzymes - chemistry
Isoenzymes - metabolism
L-Lactate Dehydrogenase - antagonists & inhibitors
L-Lactate Dehydrogenase - chemistry
L-Lactate Dehydrogenase - metabolism
lactate dehydrogenase C4
Lagomorpha
Molecular Docking Simulation
Ochotona curzoniae
virtual screening
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Studies indicated that lactate dehydrogenase C4 (LDH-C4) was a good target protein for development of contraceptive drugs. Virtual screening and in vitro enzyme assay using pika LDH-C4 as target protein revealed NSC61610, NSC215718, and NSC345647 with K i of 7.8, 27, and 41 μM separately. This study might be helpful for development of pika contraceptive drugs.
ISSN:0916-8451
1347-6947
DOI:10.1080/09168451.2014.890038