Structure and function of the ependymal barrier and diseases associated with ependyma disruption

The neuroepithelium is a germinal epithelium containing progenitor cells that produce almost all of the central nervous system cells, including the ependyma. The neuroepithelium and ependyma constitute barriers containing polarized cells covering the embryonic or mature brain ventricles, respectivel...

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Bibliographic Details
Published in:Tissue barriers 2014-01, Vol.2 (1), p.e28426-e28426
Main Authors: Jiménez, Antonio J, Domínguez-Pinos, María-Dolores, Guerra, María M, Fernández-Llebrez, Pedro, Pérez-Fígares, José-Manuel
Format: Article
Language:English
Subjects:
aquaporin 4
astrocyte reaction
cell junctions
cilia
development
Ependyma
hydrocephalus
neural tube defects
Review
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Summary:The neuroepithelium is a germinal epithelium containing progenitor cells that produce almost all of the central nervous system cells, including the ependyma. The neuroepithelium and ependyma constitute barriers containing polarized cells covering the embryonic or mature brain ventricles, respectively; therefore, they separate the cerebrospinal fluid that fills cavities from the developing or mature brain parenchyma. As barriers, the neuroepithelium and ependyma play key roles in the central nervous system development processes and physiology. These roles depend on mechanisms related to cell polarity, sensory primary cilia, motile cilia, tight junctions, adherens junctions and gap junctions, machinery for endocytosis and molecule secretion, and water channels. Here, the role of both barriers related to the development of diseases, such as neural tube defects, ciliary dyskinesia, and hydrocephalus, is reviewed.
ISSN:2168-8362
2168-8370
2168-8370
DOI:10.4161/tisb.28426