Irreversible magnetoporation of micro-organisms in high pulsed magnetic fields

Electroporation is an appealing way of stimulating living cells, which causes permanent or temporary nanoporosities in the structure of the biological objects. However, the technique has a disadvantage such as a requirement of contact between the electrodes and the cell medium. In this review, a met...

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Bibliographic Details
Published in:IET nanobiotechnology 2014-09, Vol.8 (3), p.157-162
Main Authors: Novickij, Vitalij, Grainys, Audrius, Novickij, Jurij, Markovskaja, Svetlana
Format: Article
Language:English
Subjects:
Achlya americana
antifungal treatment
Apoptosis - physiology
Biological and medical sciences
biological techniques
biotechnological field
Biotechnology
cancer
Cell Fractionation - methods
cell medium
Cell Membrane Permeability - physiology
Cell Membrane Permeability - radiation effects
Cell Survival - physiology
Cell Survival - radiation effects
cellular biophysics
contactless treatment
Dose-Response Relationship, Radiation
Electroporation - methods
eukaryotic microorganisms Achlya americana
Fundamental and applied biological sciences. Psychology
high pulsed magnetic fields
irreversible electroporation
irreversible magnetoporation
living cell stimulation
Magnetic Fields
microorganisms
Nanopores - ultrastructure
permanent nanoporosity
porosity
Radiation Dosage
Saprolegnia - cytology
Saprolegnia - physiology
Saprolegnia - radiation effects
Saprolegnia diclina
Species Specificity
temporary nanoporosity
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Summary:Electroporation is an appealing way of stimulating living cells, which causes permanent or temporary nanoporosities in the structure of the biological objects. However, the technique has a disadvantage such as a requirement of contact between the electrodes and the cell medium. In this review, a methodology of contactless treatment of the biological objects using pulsed magnetic fields is proposed. The eukaryotic micro-organisms Achlya americana and Saprolegnia diclina have been used in the study and magnetic fields up to 7 T were applied, which caused effects similar to irreversible electroporation resulting in the death of the species. The proposed technique is applicable for different types of the biological cells or micro-organisms and possibly can be used in the area of cancer, antifungal treatment and other biotechnological fields.
ISSN:1751-8741
1751-875X
1751-875X
DOI:10.1049/iet-nbt.2013.0005