Increased serum heme oxygenase-1 levels as a diagnostic marker of oxidative stress in preeclampsia

Objective: To evaluate the utility of serum biomarkers in the diagnosis of preeclampsia (PE) and also investigate possible correlation with pathogenesis of PE. Methods: Maternal serum concentrations of heme oxygenase-1 (HO1) and N-myc downstream-regulated gene 1 (NDRG1) were measured at 27-34 weeks...

Full description

Saved in:
Bibliographic Details
Published in:Hypertension in pregnancy 2014-11, Vol.33 (4), p.488-497
Main Authors: Erdemli, Hac Kemal, Y ld r mlar, P nar, Alper, Tayfun Ya ar, Kocaba, Ramazan, Salis, Osman, Bedir, Abdulkerim
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biomarkers - blood
Case-Control Studies
Cell Cycle Proteins - blood
Female
Heme oxygenase 1
Heme Oxygenase-1 - blood
Humans
Intracellular Signaling Peptides and Proteins - blood
N-myc downstream-regulated gene 1
Oxidative Stress
Pre-Eclampsia - blood
preeclampsia
Pregnancy
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective: To evaluate the utility of serum biomarkers in the diagnosis of preeclampsia (PE) and also investigate possible correlation with pathogenesis of PE. Methods: Maternal serum concentrations of heme oxygenase-1 (HO1) and N-myc downstream-regulated gene 1 (NDRG1) were measured at 27-34 weeks of gestation in a case-control study of 33 pregnant women diagnosed with PE and in 43 normotensive pregnant women without proteinuria. The Mann-Whitney U test and Spearman's correlation were used for statistical analysis. Results: The median serum HO1 level was found to be significantly higher in the PE group [76.7 ng/ml (23.4-445.7)] than control group [55.9 ng/ml (3.7-354.3)] (p = 0.006). Positive correlation was found between HO1 levels with presence of PE (r = 0.316, p = 0.005). There was no significant difference in NDRG1 values between the two groups (p = 0.226). Conclusions: Serum HO1 levels were found to be increased in patients with PE compared with normotensive pregnant women.
ISSN:1064-1955
1525-6065
DOI:10.3109/10641955.2014.946613