"Smart" theranostic lanthanide nanoprobes with simultaneous up-conversion fluorescence and tunable T1-T2 magnetic resonance imaging contrast and near-infrared activated photodynamic therapy

The current work reports a type of "smart" lanthanide-based theranostic nanoprobe, NaDyF4:Yb(3+)/NaGdF4:Yb(3+),Er(3+), which is able to circumvent the up-converting poisoning effect of Dy(3+) ions to give efficient near infrared (980 nm) triggered up-conversion fluorescence, and offers not...

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Bibliographic Details
Published in:Nanoscale 2014-11, Vol.6 (21), p.12609
Main Authors: Zhang, Yan, Das, Gautom Kumar, Vijayaragavan, Vimalan, Xu, Qing Chi, Padmanabhan, Parasuraman, Bhakoo, Kishore K, Selvan, Subramanian Tamil, Tan, Timothy Thatt Yang
Format: Article
Language:English
Subjects:
Cell Survival
Contrast Media - chemistry
Fluorescence
HeLa Cells
Humans
Lanthanoid Series Elements - chemistry
Magnetic Resonance Imaging
Microscopy, Electron, Transmission
Microscopy, Fluorescence
Oxygen - chemistry
Photochemotherapy
Photosensitizing Agents - chemistry
Polyethylene Glycols - chemistry
Polymers - chemistry
Porphyrins - chemistry
Reactive Oxygen Species - chemistry
Singlet Oxygen - chemistry
Surface Properties
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Summary:The current work reports a type of "smart" lanthanide-based theranostic nanoprobe, NaDyF4:Yb(3+)/NaGdF4:Yb(3+),Er(3+), which is able to circumvent the up-converting poisoning effect of Dy(3+) ions to give efficient near infrared (980 nm) triggered up-conversion fluorescence, and offers not only excellent dark T2-weighted MR contrast but also tunable bright and T1-weighted MR contrast properties. Due to the efficient up-converted energy transfer from the nanocrystals to chlorin e6 (Ce6) photosensitizers loaded onto the nanocrystals, cytotoxic singlet oxygen was generated and photodynamic therapy was demonstrated. Therefore, the current multifunctional nanocrystals could be potentially useful in various image-guided diagnoses where bright or dark MRI contrast could be selectively tuned to optimize image quality, but also as an efficient and more penetrative near-infrared activated photodynamic therapy agent.
ISSN:2040-3372
DOI:10.1039/c4nr01717j