Continuous synthesis of artemisinin-derived medicines

Described is a continuous, divergent synthesis system which is coupled to continuous purification and is capable of producing four anti-malarial APIs. The system is comprised of three linked reaction modules for photooxidation/cyclization, reduction, and derivatization. A fourth module couples the c...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2014-10, Vol.5 (84), p.12652-12655
Main Authors: Gilmore, Kerry, Kopetzki, Daniel, Lee, Ju Weon, Horváth, Zoltán, McQuade, D. Tyler, Seidel-Morgenstern, Andreas, Seeberger, Peter H
Format: Article
Language:English
Subjects:
Antimalarials - chemical synthesis
Antimalarials - chemistry
Artemisia annua - chemistry
Artemisia annua - metabolism
Artemisinins - chemical synthesis
Artemisinins - chemistry
Couples
Cyclization
Medicine
Modules
Oxidation-Reduction
Photooxidation
Purification
Reduction
Streams
Synthesis
Yeasts - chemistry
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Summary:Described is a continuous, divergent synthesis system which is coupled to continuous purification and is capable of producing four anti-malarial APIs. The system is comprised of three linked reaction modules for photooxidation/cyclization, reduction, and derivatization. A fourth module couples the crude reaction stream with continuous purification to yield pure API. Continuous, convergent/divergent synthesis of four anti-malarial APIs.
ISSN:1359-7345
1364-548X
DOI:10.1039/c4cc05098c