Effects of aqueous extracts of Acacia albida stem bark on Wistar albino rats infected with Trypanosoma evansi

The effect of aqueous extract of Acacia albida stem bark was investigated in Wistar albino rats infected with Trypanosoma evansi. The extract showed highest reduction in parasitemia at the dose of 600 mg/kg body weight (bw). A dose of 300 mg/kg bw improved packed cell volume the most by 14.35%. The...

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Bibliographic Details
Published in:Natural product research 2015-06, Vol.29 (12), p.1153-1156
Main Authors: Ndidi, Uche Samuel, Umar, Ismaila Alhaji, Mohammed, Aminu, Samuel, Cosmas, Oladeru, Amos Oladiran, Yakubu, Rahinat Nimma
Format: Article
Language:English
Subjects:
Acacia - chemistry
Acacia albida
Alanine Transaminase - metabolism
Animals
aqueous extract
Aspartate Aminotransferases - metabolism
Diminazene - analogs & derivatives
Diminazene - pharmacology
Kidney - drug effects
Liver - drug effects
parasitemia
Parasitemia - drug therapy
Plant Bark - chemistry
Plant Extracts - pharmacology
Rats, Wistar
stem bark
Thiobarbituric Acid Reactive Substances - metabolism
Trypanocidal Agents - pharmacology
Trypanosoma - drug effects
Trypanosoma evansi
Trypanosomiasis - drug therapy
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Summary:The effect of aqueous extract of Acacia albida stem bark was investigated in Wistar albino rats infected with Trypanosoma evansi. The extract showed highest reduction in parasitemia at the dose of 600 mg/kg body weight (bw). A dose of 300 mg/kg bw improved packed cell volume the most by 14.35%. The group treated with 150 and 600 mg/kg bw of the extract showed significant decrease (P 
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2014.981184