Parvalbumin Increases in the Caudate Putamen of Rats with Vitamin D Hypervitaminosis

• Published in: Proceedings of the National Academy of Sciences - PNAS 1989-05, Vol.86 (10), p.3887-3890
• Main Authors: De Viragh, P. A., Haglid, K. G., Celio, M. R.
• Format: Article
• Language: English
• Subjects: Analytical, structural and metabolic biochemistry; Animals; Basal ganglia; Basal Ganglia - metabolism; Binding and carrier proteins; Biological and medical sciences; Brain; Calbindins; Calcium-Binding Proteins - metabolism; Calmodulin - metabolism; Caudate Nucleus - metabolism; Cerebral cortex; Cholecalciferol - administration & dosage; Cholecalciferols; Dose-Response Relationship, Drug; Female; Fundamental and applied biological sciences. Psychology; Hippocampus; Kidneys; Muscle Proteins - metabolism; Neurons; Nutrient excess; Parvalbumins - metabolism; Proteins; Putamen; Putamen - metabolism; Rats; S100 Calcium Binding Protein G - metabolism; S100 Proteins - metabolism; Vitamin D
• ISSN: 0027-8424; 1091-6490
• DOI: 10.1073/pnas.86.10.3887

The influence of chronic vitamin D3application on the concentration of the four calcium-binding proteins parvalbumin, the 28-kDa calbindin-D, calmodulin, and S-100 was studied in various brain regions and in the kidney. Young rats were administered daily 20,000 international units of vitamin D3per kg (body weight) over a period of 4 months. This chronic treatment resulted in a clinically mild hypervitaminosis that did not affect the content of calmodulin, the 28-kDa calbindin-D, and S-100. Also the concentration of parvalbumin in the cerebral cortex, hippocampus, and kidney remained unchanged. On the other hand, parvalbumin was increased about 50% in the caudate putamen of hypervitaminotic animals as compared to controls. Our results indicate that the metabolism of parvalbumin in the caudate putamen can be influenced by variations of the blood level of this steroid hormone.