A method for the comparison of multi-platform spectral histopathology (SHP) data sets

Results of a study comparing infrared imaging data sets collected on different instruments or instrument platforms are reported, along with detailed methods developed to permit such comparisons. It was found that different instrument platforms, although employing different detector technologies and...

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Bibliographic Details
Published in:Analyst (London) 2015-04, Vol.14 (7), p.2465-2472
Main Authors: Ergin, Ay egül, Großerüschkamp, Frederik, Theisen, Oliver, Gerwert, Klaus, Remiszewski, Stan, Thompson, Clay M, Diem, Max
Format: Article
Language:English
Subjects:
Algorithms
Heterogeneity
Infrared imaging
Optical Imaging
Pathology - instrumentation
Pathology - methods
Pixels
Platforms
Reflectance
Reflectivity
Spectra
Spectrophotometry, Infrared - instrumentation
Spectrophotometry, Infrared - methods
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Summary:Results of a study comparing infrared imaging data sets collected on different instruments or instrument platforms are reported, along with detailed methods developed to permit such comparisons. It was found that different instrument platforms, although employing different detector technologies and pixel sizes, produce highly similar and reproducible spectral results. However, differences in the absolute intensity values of the reflectance data sets were observed that were caused by heterogeneity of the sample substrate in terms of reflectivity and planarity. Results of a study comparing infrared imaging data sets collected on different instruments or instrument platforms are reported, along with detailed methods developed to permit such comparisons.
ISSN:0003-2654
1364-5528
DOI:10.1039/c4an01879f