HIPK2 expression in progression of cutaneous epithelial neoplasm

Background Homeodomain‐interacting protein kinase 2 (HIPK2) is responsible for a DNA damage response, centrally regulating p53. The aberrant HIPK2 expression is known to be involved in carcinogenesis in several malignancies. However, the correlation of HIPK2 expression along with progression of cuta...

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Bibliographic Details
Published in:International journal of dermatology 2015-03, Vol.54 (3), p.347-354
Main Authors: Kwon, Mi Jung, Min, Soo Kee, Seo, Jinwon, Kim, Dong Hoon, Sung, Chang Ohk, Lim, Man Sup, Cho, Jiwoong, Park, Hye-Rim
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Bowen's Disease - chemistry
Bowen's Disease - genetics
Bowen's Disease - pathology
Carcinoma, Basal Cell - chemistry
Carcinoma, Basal Cell - genetics
Carcinoma, Basal Cell - pathology
Carcinoma, Squamous Cell - chemistry
Carcinoma, Squamous Cell - genetics
Carcinoma, Squamous Cell - pathology
Carrier Proteins - analysis
Carrier Proteins - genetics
Disease Progression
Female
Gene Expression
Humans
Keratoacanthoma - genetics
Keratoacanthoma - metabolism
Keratoacanthoma - pathology
Keratosis, Actinic - genetics
Keratosis, Actinic - metabolism
Keratosis, Actinic - pathology
Male
Middle Aged
Neoplasm Invasiveness
Protein-Serine-Threonine Kinases - analysis
Protein-Serine-Threonine Kinases - genetics
Proto-Oncogene Proteins c-mdm2 - analysis
RNA, Messenger - analysis
Skin Neoplasms - chemistry
Skin Neoplasms - genetics
Skin Neoplasms - pathology
Tumor Suppressor Protein p53 - analysis
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Summary:Background Homeodomain‐interacting protein kinase 2 (HIPK2) is responsible for a DNA damage response, centrally regulating p53. The aberrant HIPK2 expression is known to be involved in carcinogenesis in several malignancies. However, the correlation of HIPK2 expression along with progression of cutaneous epithelial neoplasm has not been investigated. Methods Using immunohistochemistry and real‐time reverse transcription–polymerase chain reaction, we examined the correlation between HIPK2 and HIPK2‐related protein expressions and the progression of some cutaneous epithelial neoplasms (i.e., actinic keratosis, Bowen's disease, keratoacanthoma, squamous cell carcinoma, and basal cell carcinoma). Results HIPK2 expression was distinct between preinvasive and invasive lesions: the expression decreased in keratoacanthoma (none of eight) and squamous cell carcinoma (five of 35) compared to actinic keratosis (12 of 19) and Bowen's disease (10 of 23) (P 
ISSN:0011-9059
1365-4632
DOI:10.1111/ijd.12664