Hypertension

Raised blood pressure is the biggest single contributor to the global burden of disease and to global mortality. The numbers of people affected and the prevalence of high blood pressure worldwide are expected to increase over the next decade. Preventive strategies are therefore urgently needed, espe...

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Bibliographic Details
Published in:The Lancet (British edition) 2015-08, Vol.386 (9995), p.801
Main Authors: Poulter, Neil R, Prabhakaran, Dorairaj, Caulfield, Mark
Format: Article
Language:English
Subjects:
Antihypertensive Agents - therapeutic use
Biomedical Technology
Catheter Ablation - methods
Developing Countries
Drug Combinations
Drug Resistance
Drug Therapy, Combination
Female
Humans
Hypertension - diagnosis
Hypertension - epidemiology
Hypertension - therapy
Male
Practice Guidelines as Topic
Randomized Controlled Trials as Topic
Sympathectomy - methods
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Summary:Raised blood pressure is the biggest single contributor to the global burden of disease and to global mortality. The numbers of people affected and the prevalence of high blood pressure worldwide are expected to increase over the next decade. Preventive strategies are therefore urgently needed, especially in less developed countries, and management of hypertension must be optimised. Genetic advances in some rare causes of hypertension have been made lately, but the aggregate effect on blood pressure of all the genetic loci identified to date is small. Hence, intervention on key environmental determinants and effective implementation of trial-based therapies are needed. Three-drug combinations can control hypertension in about 90% of patients but only if resources allow identification of patients and drug delivery is affordable. Furthermore, assessment of optimal drug therapy for each ethnic group is needed.
ISSN:1474-547X