New inflammatory markers for prediction of non-dipper blood pressure pattern in patients with essential hypertension: Serum YKL-40/Chitinase 3-like protein 1 levels and echocardiographic epicardial adipose tissue thickness

The aim of the present study was to investigate whether YKL-40 levels and epicardial adipose tissue (EAT) thickness were associated with non-dipping pattern in essential hypertension (HT). Age- and sex-matched 40 dipper hypertensive patients and 40 non-dipper hypertensive patients were included in t...

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Bibliographic Details
Published in:Clinical and experimental hypertension (1993) 2015-08, Vol.37 (6), p.505-510
Main Authors: Bakirci, Eftal Murat, Degirmenci, Husnu, Hamur, Hikmet, Gunay, Murat, Gulhan, Barıs, Aydin, Merve, Kucuksu, Zafer, Ceyhun, Gokhan, Topal, Ergun
Format: Article
Language:English
Subjects:
Adipokines - blood
Adipose Tissue - diagnostic imaging
Biomarkers - blood
Blood Pressure - physiology
C-Reactive Protein - metabolism
Chitinase-3-Like Protein 1
Cross-Sectional Studies
Dipper
Echocardiography - methods
epicardial adipose tissue
Essential Hypertension
Female
Glycoproteins
Humans
Hypertension - blood
Hypertension - diagnostic imaging
Hypertension - physiopathology
inflammation
Lectins - blood
Male
Middle Aged
non-dipper
Pericardium - diagnostic imaging
YKL-40
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Summary:The aim of the present study was to investigate whether YKL-40 levels and epicardial adipose tissue (EAT) thickness were associated with non-dipping pattern in essential hypertension (HT). Age- and sex-matched 40 dipper hypertensive patients and 40 non-dipper hypertensive patients were included in the study. Non-dippers had significantly increased EAT thickness and higher YKL-40 and high-sensitivity C-reactive protein levels than dippers. Multivariate logistic regression analysis showed that the EAT thickness and serum levels of YKL-40 and high-sensitivity C-reactive protein were independent predictors of non-dipping pattern in essential HT. In essential HT, presence of non-dipping pattern is associated with increased inflammatory response.
ISSN:1064-1963
1525-6006
DOI:10.3109/10641963.2015.1013122