Serum visinin-like protein-1 in concussed professional ice hockey players

• Published in: Brain injury 2015, Vol.29 (7-8), p.872-876
• Main Authors: Shahim, Pashtun, Mattsson, Niklas, Macy, Elizabeth M., Crimmins, Dan L., Ladenson, Jack H., Zetterberg, Henrik, Blennow, Kaj, Tegner, Yelverton
• Format: Article
• Language: English
• Subjects: Adult; ALZHEIMER-DISEASE; Biomarker; BIOMARKERS; Biomarkers - blood; Biomarkers - cerebrospinal fluid; BLOOD; Brain Concussion - blood; Brain Concussion - cerebrospinal fluid; Brain Concussion - physiopathology; brain injury; CEREBROSPINAL-FLUID; Clinical Medicine; concussion; Female; Health Science; Hockey; Humans; Hälsovetenskap; ice hockey; INTERNATIONAL-CONFERENCE; Klinisk medicin; Male; Neurocalcin - blood; Neurocalcin - cerebrospinal fluid; Neurosciences; OVEREXPRESSION; Predictive Value of Tests; Prospective Studies; Rehabilitation; Reproducibility of Results; Risk Factors; SPORT; STATEMENT; Sweden - epidemiology; TRAUMATIC BRAIN-INJURY; VILIP-1
• ISSN: 0269-9052; 1362-301X; 1362-301X
• DOI: 10.3109/02699052.2015.1018324

Primary objective: Visinin-like protein-1 (VILIP-1) has shown potential utility as a biomarker for neuronal injury in cerebrospinal fluid. This study investigated serum VILIP-1 as a diagnostic and prognostic marker in sports-related concussion. Methods: This multi-centre prospective cohort study involved the 12 teams of the professional ice hockey league in Sweden. A total of 288 players consented to participate in the study. Thirty-five players sustained concussions, of whom 28 underwent repeated blood samplings at 1, 12, 36 and 144 hours after the trauma or when the player returned to play (7-90+ days). Main outcomes and results: The highest levels of VILIP-1 were measured 1 hour after concussion and the levels decreased during rehabilitation, reaching a minimum level at the 36-hour sampling. However, the levels of serum VILIP-1 at 1 hour after concussion were not significantly higher than pre-season baseline values. Serum levels of VILIP-1 1 hour post-concussion did not correlate with the number of days for the concussion symptoms to resolve. Further, serum levels of VILIP-1 increased after a friendly game in players who were not concussed. Conclusions: These results provide evidence that serum VILIP-1 may not be a useful biomarker for diagnosis and prognosis of sports-related concussion.