CoQ10 Function and Role in Heart Failure and Ischemic Heart Disease

Coenzyme Q (CoQ) is an essential lipid of cells present in all cellular compartments. The functions of CoQ in mitochondrial respiration and as an antioxidant are established, although the lipid likely has additional, presently unknown, roles. While the therapeutic utility of CoQ 10 supplements is re...

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Bibliographic Details
Published in:Annual review of nutrition 2015-07, Vol.35, p.175-213
Main Authors: Ayer, Anita, Macdonald, Peter, Stocker, Roland
Format: Article
Language:English
Subjects:
Age Factors
Animals
Antioxidants
cardiovascular disease
Diet
Dietary Supplements
Heart Failure - drug therapy
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects
Muscle, Skeletal
Muscular Diseases - chemically induced
Muscular Diseases - prevention & control
Myocardial Ischemia - drug therapy
subcellular distribution
therapy
Tissue Distribution
ubiquinol
ubiquinone
Ubiquinone - administration & dosage
Ubiquinone - analogs & derivatives
Ubiquinone - deficiency
Ubiquinone - physiology
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Description
Summary:Coenzyme Q (CoQ) is an essential lipid of cells present in all cellular compartments. The functions of CoQ in mitochondrial respiration and as an antioxidant are established, although the lipid likely has additional, presently unknown, roles. While the therapeutic utility of CoQ 10 supplements is recognized in the rare cases of primary CoQ 10 deficiencies, a potential role for CoQ 10 supplements in cardiovascular disease, particularly heart failure, has also been studied for over 40 years. This review summarizes our current knowledge in these areas derived from animal studies and human trials. Current evidence for a benefit of CoQ 10 supplements in diseases other than primary CoQ 10 deficiencies is insufficient.
ISSN:0199-9885
1545-4312
DOI:10.1146/annurev-nutr-071714-034258