Differences in 24-h blood pressure profile of Japanese hypertensive patients under ARB treatment

Blood pressure (BP) control throughout the entire day is recommended for cardiovascular protection. Angiotensin-II receptor blockers (ARBs) are widely used in hypertensive patients because of beneficial class effects. It is uncertain, however, whether are there any differences in 24-h BP profiles am...

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Bibliographic Details
Published in:Clinical and experimental hypertension (1993) 2015-10, Vol.37 (7), p.574-579
Main Authors: Kita, Toshihiro, Sakima, Atsushi, Yokota, Naoto, Tamaki, Noboru, Etoh, Takuma, Shimokubo, Toru, Nakada, Seigo, Takishita, Shuichi, Ohya, Yusuke, Kitamura, Kazuo
Format: Article
Language:English
Subjects:
Aged
ambulatory blood pressure monitoring
Angiotensin Receptor Antagonists - administration & dosage
Angiotensin Receptor Antagonists - pharmacokinetics
Angiotensin-II receptor blocker
Benzimidazoles - administration & dosage
Benzimidazoles - pharmacokinetics
Blood Pressure - drug effects
Blood Pressure Monitoring, Ambulatory - methods
Cross-Sectional Studies
Female
Humans
hypertension
Hypertension - drug therapy
Hypertension - epidemiology
Hypertension - physiopathology
Imidazoles - administration & dosage
Imidazoles - pharmacokinetics
Japan - epidemiology
Japanese
Male
Middle Aged
pulse pressure
Tetrazoles - administration & dosage
Tetrazoles - pharmacokinetics
Therapeutic Equivalency
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Summary:Blood pressure (BP) control throughout the entire day is recommended for cardiovascular protection. Angiotensin-II receptor blockers (ARBs) are widely used in hypertensive patients because of beneficial class effects. It is uncertain, however, whether are there any differences in 24-h BP profiles among ARBs. We examined ambulatory blood pressure monitoring (ABPM) among 211 Japanese hypertensive patients (age, 69.4 ± 9.6 years; female, 59.2%) under treatment with five different ARBs. Patients were divided into five groups according to ARBs prescribed. Patient backgrounds were almost identical in all the groups and there were no differences in office, 24-h and daytime BP; however, nighttime BP with olmesartan was significantly lower than with other ARBs. Office BPs with candesartan and telmisartan, but not other ARBs, correlated well with 24-h BP (p 
ISSN:1064-1963
1525-6006
DOI:10.3109/10641963.2015.1026042