Exclusive Radiotherapy for Early-stage Glottic Cancer: A Single-institution Retrospective Analysis with a Focus on Voice Quality

To report on clinical outcomes of patients with early-stage glottic cancer treated with exclusive radiotherapy with specific analysis of voice quality. A consecutive cohort of 55 patients with early glottic cancer was retrospectively analyzed. Patients were treated with exclusive radiation up to a c...

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Bibliographic Details
Published in:Anticancer research 2015-07, Vol.35 (7), p.4155
Main Authors: Potenza, Ilenia, Franco, Pierfrancesco, Moretto, Francesco, Badellino, Serena, Balcet, Vittoria, Rossi, Giuseppe, Landolfo, Vincenzo, Riva, Giuseppe, Pecorari, Giancarlo, Ragona, Riccardo, Rampino, Monica, Ricardi, Umberto
Format: Article
Language:English
Subjects:
Aged
Carcinoma, Squamous Cell - radiotherapy
Female
Glottis - radiation effects
Humans
Laryngeal Neoplasms - radiotherapy
Male
Middle Aged
Retrospective Studies
Voice Quality - radiation effects
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Summary:To report on clinical outcomes of patients with early-stage glottic cancer treated with exclusive radiotherapy with specific analysis of voice quality. A consecutive cohort of 55 patients with early glottic cancer was retrospectively analyzed. Patients were treated with exclusive radiation up to a conventionally fractionated total dose of 66-70 Gy with a 3-dimensional conformal technique. Oncological outcomes and toxicity profiles were investigated. A sub-sample of this cohort was also analyzed in terms of voice quality employing subjective and objective tools such as the Voice Handicap Index-10 (VHI-10) and the Multidimensional Voice Program (MDVP™) software and was compared to a group of similar patients treated with CO2 laser cordectomy. after a median observation time of 74.5 months, 5- and 10-year local control was 89% [95% confidence interval (CI)=70.7-93.1%] and 86% (95% CI=68.7-89.6%), respectively. Larynx-preservation rate was 91.8% (95% CI=82.4%-94.9%) at 10 years. Five- and 10-year actuarial overall survival was 72% (95% CI=50.4-79.2%) and 56% (95% CI=48.7-64.3%). Maximum detected acute toxicity included G3 dermatitis (5.4%) and G4 dyspnea (1.8%). Late toxicity profile was mild. VHI-10 scores showed a mild voice disability in both groups, with no statistically significant difference (p=0.12), even when investigating different domains. Patients treated with radiation had a lower deterioration rate in all parameters excluding low voice, interruptions of sound and diplophony. Exclusive radiation proved an effective treatment for patients with early glottic cancer in terms of both oncological outcome and voice quality.
ISSN:1791-7530