In vitro evaluation of the antioxidant and antimicrobial activity of DIMBOA [2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one]

The aim of this study was to evaluate the in vitro antioxidant and antimicrobial properties of the natural cyclic hydroxamic acid: 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one (DIMBOA). Antioxidant activity of the isolated DIMBOA was examined using DPPH, FRAP and ABTS tests. It was found that...

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Bibliographic Details
Published in:Natural product research 2016-06, Vol.30 (11), p.1305-1308
Main Authors: Gleńsk, Michał, Gajda, Beata, Franiczek, Roman, Krzyżanowska, Barbara, Biskup, Izabela, Włodarczyk, Maciej
Format: Article
Language:English
Subjects:
ABTS
Animals
Anti-Bacterial Agents - pharmacology
Anti-Infective Agents - pharmacology
Antifungal Agents - pharmacology
antimicrobial
antioxidant
Antioxidants - pharmacology
Benzoxazines - pharmacology
Biological Products
DIMBOA
DPPH
Escherichia coli
Escherichia coli - drug effects
FRAP
Free Radical Scavengers
Microbial Sensitivity Tests
Saccharomyces cerevisiae
Saccharomyces cerevisiae - drug effects
Staphylococcus aureus
Staphylococcus aureus - drug effects
Zea mays
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Summary:The aim of this study was to evaluate the in vitro antioxidant and antimicrobial properties of the natural cyclic hydroxamic acid: 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one (DIMBOA). Antioxidant activity of the isolated DIMBOA was examined using DPPH, FRAP and ABTS tests. It was found that DIMBOA exhibits a potent free-radical scavenging activity and a weaker iron (III) ions reducing activity. Antimicrobial activity against selected G(+), G(-) bacterial strains and against yeasts-like reference strains of fungi was investigated using disk-diffusion method. It has been shown that DIMBOA possess growth inhibitory properties against many strains of studied bacteria and fungi, such as Staphylococcus aureus, Escherichia coli as well as against Saccharomyces cerevisiae.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2015.1054284