Additive effect of Lygodium venustum SW. in association with gentamicin

The aim of this work was to evaluate the interactions between gentamicin and the ethanol extract of the fern Lygodium venustum SW (EELV). The ethanol extract of L. venustum was obtained, the phytocompounds were identified and the EELV was assayed by the checkerboard method with gentamicin against tw...

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Bibliographic Details
Published in:Natural product research 2016-08, Vol.30 (16), p.1851-1853
Main Authors: Morais-Braga, Maria F. B., Souza, Teógenes M., Santos, Karla K. A., Guedes, Gláucia M. M., Andrade, Jacqueline C., Tintino, Saulo R., Sobral-Souza, Celestina E., Costa, José G. M., Saraiva, Antonio A. F., Coutinho, Henrique D. M.
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
checkerboard method
Drug Evaluation, Preclinical - methods
Drug Resistance, Multiple, Bacterial - drug effects
Drug Synergism
Escherichia coli - drug effects
Ethanol - chemistry
ethanol extract
Ferns - chemistry
gentamicin
Gentamicins - pharmacology
Lygodium venustum
Microbial Sensitivity Tests
Plant Extracts - chemistry
Plant Extracts - pharmacology
Staphylococcus aureus - drug effects
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Summary:The aim of this work was to evaluate the interactions between gentamicin and the ethanol extract of the fern Lygodium venustum SW (EELV). The ethanol extract of L. venustum was obtained, the phytocompounds were identified and the EELV was assayed by the checkerboard method with gentamicin against two bacterial strains multiresistant to antibiotics. The antibiotic activity of gentamicin, when associated with the extract, was enhanced in an additive manner against both strains. The results indicated that L. venustum can be a source of secondary metabolites to be used in association with antibiotics as aminoglycosides in the antibiotic chemotherapy against resistant bacteria.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2015.1074227