Designing Genetic Feedback Controllers

By incorporating feedback around systems we wish to manipulate, it is possible to improve their performance and robustness properties to meet pre-specified design objectives. For decades control engineers have been successfully implementing feedback controllers for complex mechanical and electrical...

Full description

Saved in:
Bibliographic Details
Published in:IEEE transactions on biomedical circuits and systems 2015-08, Vol.9 (4), p.475-484
Main Authors: Harris, Andreas W. K., Dolan, James A., Kelly, Ciaran L., Anderson, James, Papachristodoulou, Antonis
Format: Article
Language:English
Subjects:
Adaptive control
Biological
Biological system modeling
Circuits
Control systems
Control theory
Controllers
Design engineering
Feedback
Feedback control
Genetic Engineering - methods
Genetics
Models, Biological
Proteins
robust control
Synthetic Biology - methods
systems and synthetic biology
Transfer functions
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:By incorporating feedback around systems we wish to manipulate, it is possible to improve their performance and robustness properties to meet pre-specified design objectives. For decades control engineers have been successfully implementing feedback controllers for complex mechanical and electrical systems such as aircraft and sports cars. Natural biological systems use feedback extensively for regulation and adaptation but apart from the most basic designs, there is no systematic framework for designing feedback controllers in Synthetic Biology. In this paper we describe how classical approaches from linear control theory can be used to close the loop. This includes the design of genetic circuits using feedback control and the presentation of a biological phase lag controller.
ISSN:1932-4545
1940-9990
DOI:10.1109/TBCAS.2015.2458435