THE CONTENT OF LIPIDS AND PRODUCTS OF THEIR PEROXIDATION OF RAT THYMOCYTES IN EXPERIMENTAL ULCEROGENESIS

The work is dedicated to the research of the content of lipids and products of their peroxidation in rats thymocytes in experimental ulceration. It was found significant increase of the content of lipid peroxidation products diene conjugates (DC), malondialdehyde (MDA), schiff base (SB) in experimen...

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Published in:Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) Ukraine : 1994), 2015, Vol.61 (3), p.59
Main Authors: Kovaleva, V A, Shelest, D V, Ostapchenko, L I
Format: Article
Language:Ukrainian
Subjects:
Animals
Disease Models, Animal
Female
Lipid Metabolism - immunology
Lipid Peroxidation - immunology
Lipid Peroxides - metabolism
Male
Rats
Stomach Ulcer - etiology
Stomach Ulcer - immunology
Stomach Ulcer - metabolism
Thymocytes - immunology
Thymocytes - metabolism
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Summary:The work is dedicated to the research of the content of lipids and products of their peroxidation in rats thymocytes in experimental ulceration. It was found significant increase of the content of lipid peroxidation products diene conjugates (DC), malondialdehyde (MDA), schiff base (SB) in experimental models of gastric ulcers (ethanol and stress). It was established that under ethanol gastric the contents of DC increases by 1.8 times, MDA by 2.1 and SB by 1.3 times relative to control values. Under stress model it was observed an increase in the number of DC by 2 times, MDA by 1.9 and SB by 1.3 times relative to control. When ethanol and stress ulcers cholesterol increased by 1.7 and 1.5 times, triacylglycerol by 2 and 2.3 times and fatty acids by 2.2 and 1.9 times, respectively, relative to controls. Phosphatidylethanolamine content decreases by 1.5 and 1.3 times compared to control. Also, the stress model, it was observed reduction of phosphatidylinositol by 1.3 times and increased lizofosfatydylholinu by 1.7 times compared to control. Therefore, our studies indicate quantitative changes of lipid content (neutral- and phospholipids) in rats' thymocytes under experimental (ethanol and stress) ulceration. The reason of this changes may be activation of lipid peroxidation, as shown by the increase of lipid peroxidation products' (DK, MDA, SB) content.
ISSN:2522-9028