Molecular Profiles of Prostate Cancer: To Treat or Not to Treat

A major dilemma in the selection of treatment for men with prostate cancer is the difficulty in accurately characterizing the risk posed by the cancer. This uncertainty has led physicians to recommend aggressive therapy for most men diagnosed with prostate cancer and has led to concerns about the be...

Full description

Saved in:
Bibliographic Details
Published in:Annual review of medicine 2016-01, Vol.67 (1), p.119-135
Main Authors: Sternberg, Itay A, Vela, Ian, Scardino, Peter T
Format: Article
Language:English
Subjects:
active surveillance
Biomarkers, Tumor - genetics
Decision making
DNA Copy Number Variations
Gene Expression Profiling - methods
genomic classifier
Genomics
Humans
Male
Medical prognosis
Patient Selection
Prostate cancer
Prostatic Neoplasms - blood
Prostatic Neoplasms - genetics
Prostatic Neoplasms - pathology
Prostatic Neoplasms - therapy
Proteomics
Risk Assessment
risk stratification
Citations: Items that this one cites
Items that cite this one
Online Access:Request full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A major dilemma in the selection of treatment for men with prostate cancer is the difficulty in accurately characterizing the risk posed by the cancer. This uncertainty has led physicians to recommend aggressive therapy for most men diagnosed with prostate cancer and has led to concerns about the benefits of screening and the adverse consequences of excessive treatment. Genomic analyses of prostate cancer reveal distinct patterns of alterations in the genomic landscape of the disease that show promise for improved prediction of prognosis and better medical decision making. Several molecular profiles are now commercially available and are being used to inform medical decisions. This article describes the clinical tests available for distinguishing aggressive from nonaggressive prostate cancer, reviews the new genomic tests, and discusses their advantages and limitations and the evidence for their utility in various clinical settings.
ISSN:0066-4219
1545-326X
DOI:10.1146/annurev-med-060413-112226