A universal tumor cell isolation method enabled by fibrin-coated microchannels

We report a simple but effective strategy to capture tumor cells using fibrin-immobilized microchannels. It is a universal method since it shows an ability to capture both epithelial and mesenchymal tumor cells. The cell capture efficiency is up to 90%. We found that the fibrin-immobilized surfaces...

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Bibliographic Details
Published in:Analyst (London) 2016-01, Vol.141 (2), p.563-566
Main Authors: Zhang, Jinling, Fan, Z. Hugh
Format: Article
Language:English
Subjects:
Cell Line, Tumor
Cell Separation - instrumentation
Cell Separation - methods
Fibrin - chemistry
Humans
Lab-On-A-Chip Devices
Microchannels
Neoplastic Cells, Circulating - chemistry
Neoplastic Cells, Circulating - pathology
Strategy
Tumors
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Summary:We report a simple but effective strategy to capture tumor cells using fibrin-immobilized microchannels. It is a universal method since it shows an ability to capture both epithelial and mesenchymal tumor cells. The cell capture efficiency is up to 90%. We found that the fibrin-immobilized surfaces on microchannels were able to capture both epithelial and mesenchymal tumor cells.
ISSN:0003-2654
1364-5528
DOI:10.1039/c5an01783a