BRCA1-hapoinsufficiency: Unraveling the molecular and cellular basis for tissue-specific cancer

Over the past 20 years tremendous progress has been made in understanding the function of BRCA1 gene products. Yet one question still remains: why is mutation of BRCA1 typically associated with preferential development of breast and ovarian cancers and not tumors in other tissues? Here we discuss re...

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Bibliographic Details
Published in:Cell cycle (Georgetown, Tex.) Tex.), 2016-03, Vol.15 (5), p.621-627
Main Authors: Sedic, Maja, Kuperwasser, Charlotte
Format: Article
Language:English
Subjects:
Animals
BRCA1 Protein - genetics
BRCA1
haploinsufficiency
tumor suppression
Breast Neoplasms - genetics
Breast Neoplasms - pathology
Female
Genes, BRCA1
Haploinsufficiency
Humans
Mammary Glands, Human
Mutation
Organ Specificity
Ovarian Neoplasms - genetics
Review
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Summary:Over the past 20 years tremendous progress has been made in understanding the function of BRCA1 gene products. Yet one question still remains: why is mutation of BRCA1 typically associated with preferential development of breast and ovarian cancers and not tumors in other tissues? Here we discuss recent evidence documenting the effect of BRCA1-haploinsufficiency in different cells and tissues and synthesize a model for how mutations in a single BRCA1 allele in human cells might preferentially confer increased cancer risk in breast epithelial cells.
ISSN:1538-4101
1551-4005
DOI:10.1080/15384101.2016.1141841