GLYCINE RECEPTOR: MOLECULAR ORGANIZATION AND PATHOLOGY

Glycine receptor is the anion-selective channel, providing fast synaptic transmission in the central nervous system of vertebrates. Together with the nicotinic acetylcholine, GABA and serotonin (5-HT3R) receptors, it belongs to the superfamily of pentameric cys-loop receptors. In this review we brie...

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Bibliographic Details
Published in:Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) Ukraine : 1994), 2015, Vol.61 (5), p.107
Main Authors: Maleeva, G V, Bregestovski, P D
Format: Article
Language:Ukrainian
Subjects:
Acetylcholine - metabolism
Central Nervous System - metabolism
Central Nervous System - physiopathology
Gene Expression
Humans
Ion Transport
Mutation
Protein Structure, Secondary
Protein Structure, Tertiary
Receptors, GABA - chemistry
Receptors, GABA - genetics
Receptors, GABA - metabolism
Receptors, Glycine - chemistry
Receptors, Glycine - genetics
Receptors, Glycine - metabolism
Receptors, Nicotinic - chemistry
Receptors, Nicotinic - genetics
Receptors, Nicotinic - metabolism
Receptors, Serotonin, 5-HT3 - chemistry
Receptors, Serotonin, 5-HT3 - genetics
Receptors, Serotonin, 5-HT3 - metabolism
Reflex, Startle - genetics
Serotonin - metabolism
Synaptic Transmission
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Summary:Glycine receptor is the anion-selective channel, providing fast synaptic transmission in the central nervous system of vertebrates. Together with the nicotinic acetylcholine, GABA and serotonin (5-HT3R) receptors, it belongs to the superfamily of pentameric cys-loop receptors. In this review we briefly describe main functions of these transmembrane proteins, their distribution and molecular architecture. Special attention is paid to recent studies on the molecular physiology of these receptors, as well as on presenting of molecular domains responsible for their dysfunction.
ISSN:2522-9028