Loading…
GLYCINE RECEPTOR: MOLECULAR ORGANIZATION AND PATHOLOGY
Glycine receptor is the anion-selective channel, providing fast synaptic transmission in the central nervous system of vertebrates. Together with the nicotinic acetylcholine, GABA and serotonin (5-HT3R) receptors, it belongs to the superfamily of pentameric cys-loop receptors. In this review we brie...
Saved in:
| Published in: | Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) Ukraine : 1994), 2015, Vol.61 (5), p.107 |
|---|---|
| Main Authors: | , |
| Format: | Article |
| Language: | Ukrainian |
| Subjects: | |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | |
|---|---|
| cites | |
| container_end_page | |
| container_issue | 5 |
| container_start_page | 107 |
| container_title | Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) |
| container_volume | 61 |
| creator | Maleeva, G V Bregestovski, P D |
| description | Glycine receptor is the anion-selective channel, providing fast synaptic transmission in the central nervous system of vertebrates. Together with the nicotinic acetylcholine, GABA and serotonin (5-HT3R) receptors, it belongs to the superfamily of pentameric cys-loop receptors. In this review we briefly describe main functions of these transmembrane proteins, their distribution and molecular architecture. Special attention is paid to recent studies on the molecular physiology of these receptors, as well as on presenting of molecular domains responsible for their dysfunction. |
| format | article |
| fullrecord | <record><control><sourceid>pubmed</sourceid><recordid>TN_cdi_pubmed_primary_26845851</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>26845851</sourcerecordid><originalsourceid>FETCH-pubmed_primary_268458513</originalsourceid><addsrcrecordid>eNpjYeA0MjUy0rU0MLLgYOAtLs5MMjA1MjMwMzY1Z2fgMDKzMDG1MDXkZDBz94l09vRzVQhydXYNCPEPslLw9fdxdQ71cQxS8A9yd_TzjHIM8fT3U3D0c1EIcAzx8Pfxd4_kYWBNS8wpTuWF0twMcm6uIc4eugWlSbmpKfEFRZm5iUWV8TCLjAkqAAC-Zi5d</addsrcrecordid><sourcetype>Index Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>GLYCINE RECEPTOR: MOLECULAR ORGANIZATION AND PATHOLOGY</title><source>ROAD: Directory of Open Access Scholarly Resources</source><creator>Maleeva, G V ; Bregestovski, P D</creator><creatorcontrib>Maleeva, G V ; Bregestovski, P D</creatorcontrib><description>Glycine receptor is the anion-selective channel, providing fast synaptic transmission in the central nervous system of vertebrates. Together with the nicotinic acetylcholine, GABA and serotonin (5-HT3R) receptors, it belongs to the superfamily of pentameric cys-loop receptors. In this review we briefly describe main functions of these transmembrane proteins, their distribution and molecular architecture. Special attention is paid to recent studies on the molecular physiology of these receptors, as well as on presenting of molecular domains responsible for their dysfunction.</description><identifier>ISSN: 2522-9028</identifier><identifier>PMID: 26845851</identifier><language>ukr</language><publisher>Ukraine</publisher><subject>Acetylcholine - metabolism ; Central Nervous System - metabolism ; Central Nervous System - physiopathology ; Gene Expression ; Humans ; Ion Transport ; Mutation ; Protein Structure, Secondary ; Protein Structure, Tertiary ; Receptors, GABA - chemistry ; Receptors, GABA - genetics ; Receptors, GABA - metabolism ; Receptors, Glycine - chemistry ; Receptors, Glycine - genetics ; Receptors, Glycine - metabolism ; Receptors, Nicotinic - chemistry ; Receptors, Nicotinic - genetics ; Receptors, Nicotinic - metabolism ; Receptors, Serotonin, 5-HT3 - chemistry ; Receptors, Serotonin, 5-HT3 - genetics ; Receptors, Serotonin, 5-HT3 - metabolism ; Reflex, Startle - genetics ; Serotonin - metabolism ; Synaptic Transmission</subject><ispartof>Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994), 2015, Vol.61 (5), p.107</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26845851$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Maleeva, G V</creatorcontrib><creatorcontrib>Bregestovski, P D</creatorcontrib><title>GLYCINE RECEPTOR: MOLECULAR ORGANIZATION AND PATHOLOGY</title><title>Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994)</title><addtitle>Fiziol Zh</addtitle><description>Glycine receptor is the anion-selective channel, providing fast synaptic transmission in the central nervous system of vertebrates. Together with the nicotinic acetylcholine, GABA and serotonin (5-HT3R) receptors, it belongs to the superfamily of pentameric cys-loop receptors. In this review we briefly describe main functions of these transmembrane proteins, their distribution and molecular architecture. Special attention is paid to recent studies on the molecular physiology of these receptors, as well as on presenting of molecular domains responsible for their dysfunction.</description><subject>Acetylcholine - metabolism</subject><subject>Central Nervous System - metabolism</subject><subject>Central Nervous System - physiopathology</subject><subject>Gene Expression</subject><subject>Humans</subject><subject>Ion Transport</subject><subject>Mutation</subject><subject>Protein Structure, Secondary</subject><subject>Protein Structure, Tertiary</subject><subject>Receptors, GABA - chemistry</subject><subject>Receptors, GABA - genetics</subject><subject>Receptors, GABA - metabolism</subject><subject>Receptors, Glycine - chemistry</subject><subject>Receptors, Glycine - genetics</subject><subject>Receptors, Glycine - metabolism</subject><subject>Receptors, Nicotinic - chemistry</subject><subject>Receptors, Nicotinic - genetics</subject><subject>Receptors, Nicotinic - metabolism</subject><subject>Receptors, Serotonin, 5-HT3 - chemistry</subject><subject>Receptors, Serotonin, 5-HT3 - genetics</subject><subject>Receptors, Serotonin, 5-HT3 - metabolism</subject><subject>Reflex, Startle - genetics</subject><subject>Serotonin - metabolism</subject><subject>Synaptic Transmission</subject><issn>2522-9028</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNpjYeA0MjUy0rU0MLLgYOAtLs5MMjA1MjMwMzY1Z2fgMDKzMDG1MDXkZDBz94l09vRzVQhydXYNCPEPslLw9fdxdQ71cQxS8A9yd_TzjHIM8fT3U3D0c1EIcAzx8Pfxd4_kYWBNS8wpTuWF0twMcm6uIc4eugWlSbmpKfEFRZm5iUWV8TCLjAkqAAC-Zi5d</recordid><startdate>2015</startdate><enddate>2015</enddate><creator>Maleeva, G V</creator><creator>Bregestovski, P D</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>2015</creationdate><title>GLYCINE RECEPTOR: MOLECULAR ORGANIZATION AND PATHOLOGY</title><author>Maleeva, G V ; Bregestovski, P D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-pubmed_primary_268458513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>ukr</language><creationdate>2015</creationdate><topic>Acetylcholine - metabolism</topic><topic>Central Nervous System - metabolism</topic><topic>Central Nervous System - physiopathology</topic><topic>Gene Expression</topic><topic>Humans</topic><topic>Ion Transport</topic><topic>Mutation</topic><topic>Protein Structure, Secondary</topic><topic>Protein Structure, Tertiary</topic><topic>Receptors, GABA - chemistry</topic><topic>Receptors, GABA - genetics</topic><topic>Receptors, GABA - metabolism</topic><topic>Receptors, Glycine - chemistry</topic><topic>Receptors, Glycine - genetics</topic><topic>Receptors, Glycine - metabolism</topic><topic>Receptors, Nicotinic - chemistry</topic><topic>Receptors, Nicotinic - genetics</topic><topic>Receptors, Nicotinic - metabolism</topic><topic>Receptors, Serotonin, 5-HT3 - chemistry</topic><topic>Receptors, Serotonin, 5-HT3 - genetics</topic><topic>Receptors, Serotonin, 5-HT3 - metabolism</topic><topic>Reflex, Startle - genetics</topic><topic>Serotonin - metabolism</topic><topic>Synaptic Transmission</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Maleeva, G V</creatorcontrib><creatorcontrib>Bregestovski, P D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Maleeva, G V</au><au>Bregestovski, P D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>GLYCINE RECEPTOR: MOLECULAR ORGANIZATION AND PATHOLOGY</atitle><jtitle>Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994)</jtitle><addtitle>Fiziol Zh</addtitle><date>2015</date><risdate>2015</risdate><volume>61</volume><issue>5</issue><spage>107</spage><pages>107-</pages><issn>2522-9028</issn><abstract>Glycine receptor is the anion-selective channel, providing fast synaptic transmission in the central nervous system of vertebrates. Together with the nicotinic acetylcholine, GABA and serotonin (5-HT3R) receptors, it belongs to the superfamily of pentameric cys-loop receptors. In this review we briefly describe main functions of these transmembrane proteins, their distribution and molecular architecture. Special attention is paid to recent studies on the molecular physiology of these receptors, as well as on presenting of molecular domains responsible for their dysfunction.</abstract><cop>Ukraine</cop><pmid>26845851</pmid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2522-9028 |
| ispartof | Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994), 2015, Vol.61 (5), p.107 |
| issn | 2522-9028 |
| language | ukr |
| recordid | cdi_pubmed_primary_26845851 |
| source | ROAD: Directory of Open Access Scholarly Resources |
| subjects | Acetylcholine - metabolism Central Nervous System - metabolism Central Nervous System - physiopathology Gene Expression Humans Ion Transport Mutation Protein Structure, Secondary Protein Structure, Tertiary Receptors, GABA - chemistry Receptors, GABA - genetics Receptors, GABA - metabolism Receptors, Glycine - chemistry Receptors, Glycine - genetics Receptors, Glycine - metabolism Receptors, Nicotinic - chemistry Receptors, Nicotinic - genetics Receptors, Nicotinic - metabolism Receptors, Serotonin, 5-HT3 - chemistry Receptors, Serotonin, 5-HT3 - genetics Receptors, Serotonin, 5-HT3 - metabolism Reflex, Startle - genetics Serotonin - metabolism Synaptic Transmission |
| title | GLYCINE RECEPTOR: MOLECULAR ORGANIZATION AND PATHOLOGY |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T12%3A51%3A44IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=GLYCINE%20RECEPTOR:%20MOLECULAR%20ORGANIZATION%20AND%20PATHOLOGY&rft.jtitle=Fiziolohichnyi%20zhurnal%20(Kiev,%20Ukraine%20:%201994)&rft.au=Maleeva,%20G%20V&rft.date=2015&rft.volume=61&rft.issue=5&rft.spage=107&rft.pages=107-&rft.issn=2522-9028&rft_id=info:doi/&rft_dat=%3Cpubmed%3E26845851%3C/pubmed%3E%3Cgrp_id%3Ecdi_FETCH-pubmed_primary_268458513%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_id=info:pmid/26845851&rfr_iscdi=true |