Increased levels of N(ε)- Carboxy methyl lysine (N(ε)-CML) are associated with topographic alterations in retinal pigment epithelium: A preliminary study

To evaluate the association of serum levels of N(ε)- Carboxy methyl lysine (N(ε)-CML), an advanced glycation end product with topographic alterations in retinal pigment epithelium (RPE) in diabetic retinopathy on spectral domain optical coherence tomography (SD-OCT). Consecutive cases of type 2 diab...

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Bibliographic Details
Published in:Journal of diabetes and its complications 2016-07, Vol.30 (5), p.868
Main Authors: Mishra, Nibha, Saxena, Sandeep, Ruia, Surabhi, Prasad, Senthamizh, Singh, Vinita, Khanna, Vinay, Staffa, Robert, Gaspar, Ludovit, Kruzliak, Peter
Format: Article
Language:English
Subjects:
Adult
Biomarkers - blood
Case-Control Studies
Cross-Sectional Studies
Diabetes Mellitus, Type 2 - complications
Diabetic Retinopathy - blood
Diabetic Retinopathy - diagnostic imaging
Diabetic Retinopathy - physiopathology
Disease Progression
Female
Glycated Hemoglobin A - analysis
Humans
Lysine - analogs & derivatives
Lysine - blood
Male
Middle Aged
Prospective Studies
Regression Analysis
Retinal Pigment Epithelium - diagnostic imaging
Retinal Pigment Epithelium - physiopathology
Severity of Illness Index
Tertiary Care Centers
Up-Regulation
Vitreoretinopathy, Proliferative - blood
Vitreoretinopathy, Proliferative - complications
Vitreoretinopathy, Proliferative - diagnostic imaging
Vitreoretinopathy, Proliferative - physiopathology
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Summary:To evaluate the association of serum levels of N(ε)- Carboxy methyl lysine (N(ε)-CML), an advanced glycation end product with topographic alterations in retinal pigment epithelium (RPE) in diabetic retinopathy on spectral domain optical coherence tomography (SD-OCT). Consecutive cases of type 2 diabetes mellitus with no retinopathy (n=20); non-proliferative diabetic retinopathy (n=20); proliferative diabetic retinopathy (n=20) and healthy controls (n=20) between the ages of 40 and 65years were included. RPE alterations were graded on segmentation map of SD-OCT: grade 0, No RPE alterations; grade 1, RPE alterations in up to two quadrants and grade 2, RPE alterations in more than two quadrants. Serum level of N(ε)-CML and glycated hemoglobin (HbA1c) was analyzed using the standard protocol. Statistical analysis was done. Significant increase in N(ε)-CML was observed with increased severity of diabetic retinopathy (F=34.1; p
ISSN:1873-460X
DOI:10.1016/j.jdiacomp.2016.03.011