Loading…
Another DRAM involved in autophagy and cell death
Macroautophagy (hereafter referred to as autophagy) is controlled by a number of core proteins that are critical for all autophagy responses. In addition, a number of autophagy regulators have been found that are not critical for macroautophagy per se, but which play roles in regulating autophagy in...
Saved in:
| Published in: | Autophagy 2016-01, Vol.12 (3), p.603-605 |
|---|---|
| Main Authors: | , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c468t-a8d18b528a97faf21c9d4db32006d90972b7188294e409262ab5a2fcfe9794c23 |
|---|---|
| cites | |
| container_end_page | 605 |
| container_issue | 3 |
| container_start_page | 603 |
| container_title | Autophagy |
| container_volume | 12 |
| creator | Mrschtik, Michaela Ryan, Kevin M. |
| description | Macroautophagy (hereafter referred to as autophagy) is controlled by a number of core proteins that are critical for all autophagy responses. In addition, a number of autophagy regulators have been found that are not critical for macroautophagy per se, but which play roles in regulating autophagy in either selective situations or in response to specific stimuli. In a recent study, we reported the initial characterization of a new autophagy regulator encoded by TMEM150B that is related to the Damage-Regulated Autophagy Modulator, DRAM1. We have termed this factor DRAM3 for DRAM-Related/Associated Member 3. Interestingly, like DRAM1, DRAM3 regulates both autophagy and cell death, but we found these two functions of the protein are not intrinsically connected. |
| doi_str_mv | 10.1080/15548627.2015.1137412 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmed_primary_27046253</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1779427525</sourcerecordid><originalsourceid>FETCH-LOGICAL-c468t-a8d18b528a97faf21c9d4db32006d90972b7188294e409262ab5a2fcfe9794c23</originalsourceid><addsrcrecordid>eNp9kM1OwzAQhC0EolB4BFCOXFrsjR3bF0RVfiUQEoKztYmdNiiNi50W9e1J1VLBhdOu1rMz64-QM0aHjCp6yYTgKgM5BMrEkLFUcgZ75Gg9H6gsFfu7HmSPHMf4QWmaKQ2HpAeS8gxEekTYqPHt1IXk5nX0nFTN0tdLZ7smwUXr51OcrBJsbFK4uk6sw3Z6Qg5KrKM73dY-eb-7fRs_DJ5e7h_Ho6dBwTPVDlBZpnIBCrUssQRWaMttngKlmdVUS8glUwo0d5xqyABzgVAWpdNS8wLSPrna-M4X-czZwjVtwNrMQzXDsDIeK_P3pammZuKXhqs0o6A6g4utQfCfCxdbM6vi-h_YOL-IhskuCKToOPSJ2EiL4GMMrtzFMGrWuM0PbrPGbba4u73z3zfutn74doLrjaBqSh9m-OVDbU2Lq9qHMmBTVNGk_2d8A2SbjgI</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1779427525</pqid></control><display><type>article</type><title>Another DRAM involved in autophagy and cell death</title><source>PubMed Central(OpenAccess)</source><source>Taylor and Francis Science and Technology Collection</source><creator>Mrschtik, Michaela ; Ryan, Kevin M.</creator><creatorcontrib>Mrschtik, Michaela ; Ryan, Kevin M.</creatorcontrib><description>Macroautophagy (hereafter referred to as autophagy) is controlled by a number of core proteins that are critical for all autophagy responses. In addition, a number of autophagy regulators have been found that are not critical for macroautophagy per se, but which play roles in regulating autophagy in either selective situations or in response to specific stimuli. In a recent study, we reported the initial characterization of a new autophagy regulator encoded by TMEM150B that is related to the Damage-Regulated Autophagy Modulator, DRAM1. We have termed this factor DRAM3 for DRAM-Related/Associated Member 3. Interestingly, like DRAM1, DRAM3 regulates both autophagy and cell death, but we found these two functions of the protein are not intrinsically connected.</description><identifier>ISSN: 1554-8627</identifier><identifier>EISSN: 1554-8635</identifier><identifier>DOI: 10.1080/15548627.2015.1137412</identifier><identifier>PMID: 27046253</identifier><language>eng</language><publisher>United States: Taylor & Francis</publisher><subject>Animals ; Apoptosis ; Autophagic Puncta ; Autophagy ; cell death ; Cell Line, Tumor ; DRAM3 ; glucose deprivation ; Humans ; Membrane Proteins - metabolism ; Mitophagy ; Models, Biological ; TMEM150B ; Tumor Suppressor Protein p53 - metabolism</subject><ispartof>Autophagy, 2016-01, Vol.12 (3), p.603-605</ispartof><rights>2016 Taylor & Francis 2016</rights><rights>2016 Taylor & Francis 2016 Taylor & Francis</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c468t-a8d18b528a97faf21c9d4db32006d90972b7188294e409262ab5a2fcfe9794c23</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836028/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836028/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27046253$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mrschtik, Michaela</creatorcontrib><creatorcontrib>Ryan, Kevin M.</creatorcontrib><title>Another DRAM involved in autophagy and cell death</title><title>Autophagy</title><addtitle>Autophagy</addtitle><description>Macroautophagy (hereafter referred to as autophagy) is controlled by a number of core proteins that are critical for all autophagy responses. In addition, a number of autophagy regulators have been found that are not critical for macroautophagy per se, but which play roles in regulating autophagy in either selective situations or in response to specific stimuli. In a recent study, we reported the initial characterization of a new autophagy regulator encoded by TMEM150B that is related to the Damage-Regulated Autophagy Modulator, DRAM1. We have termed this factor DRAM3 for DRAM-Related/Associated Member 3. Interestingly, like DRAM1, DRAM3 regulates both autophagy and cell death, but we found these two functions of the protein are not intrinsically connected.</description><subject>Animals</subject><subject>Apoptosis</subject><subject>Autophagic Puncta</subject><subject>Autophagy</subject><subject>cell death</subject><subject>Cell Line, Tumor</subject><subject>DRAM3</subject><subject>glucose deprivation</subject><subject>Humans</subject><subject>Membrane Proteins - metabolism</subject><subject>Mitophagy</subject><subject>Models, Biological</subject><subject>TMEM150B</subject><subject>Tumor Suppressor Protein p53 - metabolism</subject><issn>1554-8627</issn><issn>1554-8635</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNp9kM1OwzAQhC0EolB4BFCOXFrsjR3bF0RVfiUQEoKztYmdNiiNi50W9e1J1VLBhdOu1rMz64-QM0aHjCp6yYTgKgM5BMrEkLFUcgZ75Gg9H6gsFfu7HmSPHMf4QWmaKQ2HpAeS8gxEekTYqPHt1IXk5nX0nFTN0tdLZ7smwUXr51OcrBJsbFK4uk6sw3Z6Qg5KrKM73dY-eb-7fRs_DJ5e7h_Ho6dBwTPVDlBZpnIBCrUssQRWaMttngKlmdVUS8glUwo0d5xqyABzgVAWpdNS8wLSPrna-M4X-czZwjVtwNrMQzXDsDIeK_P3pammZuKXhqs0o6A6g4utQfCfCxdbM6vi-h_YOL-IhskuCKToOPSJ2EiL4GMMrtzFMGrWuM0PbrPGbba4u73z3zfutn74doLrjaBqSh9m-OVDbU2Lq9qHMmBTVNGk_2d8A2SbjgI</recordid><startdate>20160101</startdate><enddate>20160101</enddate><creator>Mrschtik, Michaela</creator><creator>Ryan, Kevin M.</creator><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160101</creationdate><title>Another DRAM involved in autophagy and cell death</title><author>Mrschtik, Michaela ; Ryan, Kevin M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c468t-a8d18b528a97faf21c9d4db32006d90972b7188294e409262ab5a2fcfe9794c23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Apoptosis</topic><topic>Autophagic Puncta</topic><topic>Autophagy</topic><topic>cell death</topic><topic>Cell Line, Tumor</topic><topic>DRAM3</topic><topic>glucose deprivation</topic><topic>Humans</topic><topic>Membrane Proteins - metabolism</topic><topic>Mitophagy</topic><topic>Models, Biological</topic><topic>TMEM150B</topic><topic>Tumor Suppressor Protein p53 - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mrschtik, Michaela</creatorcontrib><creatorcontrib>Ryan, Kevin M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Autophagy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mrschtik, Michaela</au><au>Ryan, Kevin M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Another DRAM involved in autophagy and cell death</atitle><jtitle>Autophagy</jtitle><addtitle>Autophagy</addtitle><date>2016-01-01</date><risdate>2016</risdate><volume>12</volume><issue>3</issue><spage>603</spage><epage>605</epage><pages>603-605</pages><issn>1554-8627</issn><eissn>1554-8635</eissn><abstract>Macroautophagy (hereafter referred to as autophagy) is controlled by a number of core proteins that are critical for all autophagy responses. In addition, a number of autophagy regulators have been found that are not critical for macroautophagy per se, but which play roles in regulating autophagy in either selective situations or in response to specific stimuli. In a recent study, we reported the initial characterization of a new autophagy regulator encoded by TMEM150B that is related to the Damage-Regulated Autophagy Modulator, DRAM1. We have termed this factor DRAM3 for DRAM-Related/Associated Member 3. Interestingly, like DRAM1, DRAM3 regulates both autophagy and cell death, but we found these two functions of the protein are not intrinsically connected.</abstract><cop>United States</cop><pub>Taylor & Francis</pub><pmid>27046253</pmid><doi>10.1080/15548627.2015.1137412</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1554-8627 |
| ispartof | Autophagy, 2016-01, Vol.12 (3), p.603-605 |
| issn | 1554-8627 1554-8635 |
| language | eng |
| recordid | cdi_pubmed_primary_27046253 |
| source | PubMed Central(OpenAccess); Taylor and Francis Science and Technology Collection |
| subjects | Animals Apoptosis Autophagic Puncta Autophagy cell death Cell Line, Tumor DRAM3 glucose deprivation Humans Membrane Proteins - metabolism Mitophagy Models, Biological TMEM150B Tumor Suppressor Protein p53 - metabolism |
| title | Another DRAM involved in autophagy and cell death |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T01%3A16%3A33IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Another%20DRAM%20involved%20in%20autophagy%20and%20cell%20death&rft.jtitle=Autophagy&rft.au=Mrschtik,%20Michaela&rft.date=2016-01-01&rft.volume=12&rft.issue=3&rft.spage=603&rft.epage=605&rft.pages=603-605&rft.issn=1554-8627&rft.eissn=1554-8635&rft_id=info:doi/10.1080/15548627.2015.1137412&rft_dat=%3Cproquest_pubme%3E1779427525%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c468t-a8d18b528a97faf21c9d4db32006d90972b7188294e409262ab5a2fcfe9794c23%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1779427525&rft_id=info:pmid/27046253&rfr_iscdi=true |