Association between rs6887695 and 3′-untranslated region polymorphisms within the interleukin-12B gene and susceptibility to autoimmune diseases in Asian and European population: A meta-analysis

• Published in: Autoimmunity (Chur, Switzerland) Switzerland), 2016-05, Vol.49 (4), p.277-284
• Main Authors: Xiao, Jian-Ping, Wang, Xue-Rong, Zhang, Sen, Wang, Hai-Yan, Ye, Lei, Pan, Hai-Feng, Wang, De-Guang
• Format: Article
• Language: English
• Subjects: 3' Untranslated Regions; Alleles; Asian Continental Ancestry Group - genetics; Autoimmune disease (AD); Autoimmune Diseases - epidemiology; Autoimmune Diseases - genetics; European Continental Ancestry Group - genetics; Genetic Predisposition to Disease; Genotype; Humans; IL-12B 3′-untranslated region; IL-12B rs6887695; Interleukin-12 Subunit p40 - genetics; meta-analysis; Odds Ratio; polymorphism; Polymorphism, Single Nucleotide
• ISSN: 0891-6934; 1607-842X
• DOI: 10.3109/08916934.2016.1166215

Background: The associations between rs6887695 and 3′-untranslated region (3′-UTR) single-nucleotide polymorphisms (SNPs) within interleukin-12B (IL-12B) and autoimmune diseases (ADs) remain controversial and inconclusive. The aim of this study was to evaluate the association between IL-12B (3′-UTR A/C and rs6887695 C/G SNPs) and ADs by meta-analysis. Methods: PubMed and EMBASE were exhaustively searched for studies on the association between IL-12B SNPs and ADs. Publication bias was examined by a funnel plot and Egger's test. The robustness of the pooled results was assessed by sensitivity analysis. A fixed- or a random-effects model was applied to calculate the pooled odds ratios (ORs). Results: A total of 34 studies were included in this meta-analysis. The pooled results demonstrated that IL-12B rs6887695 SNPs were significantly associated with the risk of ADs. However, there was no significant association between IL-12B 3′-UTR SNPs and ADs. When the studies were stratified by ethnicity, significant association between IL-12B 3′-UTR SNPs and ADs was observed in both Asian and European population. In addition, allele A within 3′-UTR of IL-12B gene was found to be a protective factor for T1DM, but a risk factor for psoriasis. Conclusion: The IL-12B 3′-UTR and rs6887695 SNPs are associated with susceptibility to ADs.