Optogenetic approaches to evaluate striatal function in animal models of Parkinson disease

Optogenetics refers to the ability to control cells that have been genetically modified to express light-sensitive ion channels. The introduction of optogenetic approaches has facilitated the dissection of neural circuits. Optogenetics allows for the precise stimulation and inhibition of specific se...

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Bibliographic Details
Published in:Dialogues in clinical neuroscience 2016-03, Vol.18 (1), p.99-107
Main Authors: Parker, Krystal L., Kim, Youngcho, Alberico, Stephanie L., Emmons, Eric B., Narayanan, Nandakumar S.
Format: Article
Language:English
Subjects:
animal model
Animals
Clinical Research
Corpus Striatum - physiology
Disease Models, Animal
dopamine
Humans
Nerve Net - physiology
optogenetics
Optogenetics - methods
Optogenetics - trends
Parkinson disease
Parkinson Disease - diagnosis
Parkinson Disease - genetics
Parkinson Disease - metabolism
striatum
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Summary:Optogenetics refers to the ability to control cells that have been genetically modified to express light-sensitive ion channels. The introduction of optogenetic approaches has facilitated the dissection of neural circuits. Optogenetics allows for the precise stimulation and inhibition of specific sets of neurons and their projections with fine temporal specificity. These techniques are ideally suited to investigating neural circuitry underlying motor and cognitive dysfunction in animal models of human disease. Here, we focus on how optogenetics has been used over the last decade to probe striatal circuits that are involved in Parkinson disease, a neurodegenerative condition involving motor and cognitive abnormalities resulting from degeneration of midbrain dopaminergic neurons. The precise mechanisms underlying the striatal contribution to both cognitive and motor dysfunction in Parkinson disease are unknown. Although optogenetic approaches are somewhat removed from clinical use, insight from these studies can help identify novel therapeutic targets and may inspire new treatments for Parkinson disease. Elucidating how neuronal and behavioral functions are influenced and potentially rescued by optogenetic manipulation in animal models could prove to be translatable to humans. These insights can be used to guide future brain-stimulation approaches for motor and cognitive abnormalities in Parkinson disease and other neuropsychiatric diseases.
ISSN:1958-5969
1294-8322
1958-5969
DOI:10.31887/DCNS.2016.18.1/kparker