The resistance and transmission mechanism of Acinetobacter baumannii isolates in a tertiary care hospital, China

The aim of this study was to analyse the resistance and epidemiological data of 117 Acinetobacter baumannii isolates from Southwest Hospital, Chongqing, China. Except for polymyxin B, tigecycline, minocycline, cefoperazone/sulbactam, amikacin and levofloxacin, the resistance rates of other antimicro...

Full description

Saved in:
Bibliographic Details
Published in:Journal of chemotherapy (Florence) 2016-11, Vol.28 (6), p.476-481
Main Authors: Sun, Fengjun, Ou, Qianyi, Wang, Qian, Feng, Wei, Qiu, Xuewen, Chen, Jianhong, Liu, Yao, Xia, Peiyuan
Format: Article
Language:English
Subjects:
Acinetobacter baumannii
Acinetobacter baumannii - drug effects
Acinetobacter baumannii - genetics
Acinetobacter baumannii - isolation & purification
Acinetobacter Infections - epidemiology
Acinetobacter Infections - microbiology
Acinetobacter Infections - transmission
China
Cross Infection - epidemiology
Cross Infection - microbiology
Cross Infection - transmission
Drug Resistance, Bacterial - genetics
Humans
Pulsed-field gel electrophoresis
Resistance
Tertiary Care Centers
Transmission mechanism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The aim of this study was to analyse the resistance and epidemiological data of 117 Acinetobacter baumannii isolates from Southwest Hospital, Chongqing, China. Except for polymyxin B, tigecycline, minocycline, cefoperazone/sulbactam, amikacin and levofloxacin, the resistance rates of other antimicrobial agents were above 90%. All the clinical isolates had the bla OXA-51 gene and 114 isolates had the bla OXA-23 gene. Forty-nine isolates were found to contain the bla IMP-4 gene. PFGE data showed that 117 isolates were divided into 25 groups. Sixty-three (53.85%) were found to carry the class 1 integron, and the sequence analysis of the class 1 integron internal variable regions - five types, one of which had the bla IMP-4 gene. For the bla IMP-4 positive strain without class 1 integron, we found the flanking sequence had the TnpA gene. The result suggested that the resistance gene was widely distributed in our hospital; moreover, the modes of presence and transmission are different and complicated. The results of our study can improve the infection empirical treatment method and infection control programme.
ISSN:1120-009X
1973-9478
DOI:10.1080/1120009X.2016.1139335