The new steroidal glycosides from the aerial parts of Lepidogrammitis drymoglossoides

Two new steroidal glycosides ponasteroside C (1) and ponasteroside D (2) were isolated from the aerial parts of Lepidogrammitis drymoglossoides. Their structures were elucidated by various spectroscopic techniques (IR, HRESIMS, 1D and 2D NMR). All compounds were evaluated for their cytotoxicity agai...

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Bibliographic Details
Published in:Journal of asian natural products research 2016-09, Vol.18 (9), p.878-884
Main Authors: Wei, Hua, Jiang, Hai, Liu, Zhu-Xiang, Li, Gui, Long, Hua, He, Jian-Wu, Chen, Gong-Xi, Yang, Jun-Shan, Ma, Guo-Xu
Format: Article
Language:English
Subjects:
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - isolation & purification
Antineoplastic Agents, Phytogenic - pharmacology
cytotoic activity
Drug Screening Assays, Antitumor
Drugs, Chinese Herbal - chemistry
Drugs, Chinese Herbal - isolation & purification
Drugs, Chinese Herbal - pharmacology
Glycosides - chemistry
Glycosides - isolation & purification
Glycosides - pharmacology
HeLa Cells
Humans
Lepidogrammitis drymoglossoides
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Phytosterols - chemistry
Phytosterols - isolation & purification
Phytosterols - pharmacology
Plant Components, Aerial - chemistry
Polypodiaceae
steroidal glycosides
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Summary:Two new steroidal glycosides ponasteroside C (1) and ponasteroside D (2) were isolated from the aerial parts of Lepidogrammitis drymoglossoides. Their structures were elucidated by various spectroscopic techniques (IR, HRESIMS, 1D and 2D NMR). All compounds were evaluated for their cytotoxicity against HeLa and HCT-8 cell lines, and compounds 1 and 2 showed mild activity against all the test cell lines.
ISSN:1028-6020
1477-2213
DOI:10.1080/10286020.2016.1171757