SOX18 Expression in Non-melanoma Skin Cancer

SRY-related HMG box protein 18 (SOX18) is a transcription factor involved in a range of physiological processes, including differentiation of endothelial cells during new vessel formation. Numerous studies are being conducted to determine its role in carcinogenesis. Thirty-five cases of squamous cel...

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Published in:Anticancer research 2016-05, Vol.36 (5), p.2379
Main Authors: Ornat, Maciej, Kobierzycki, Christopher, Grzegrzolka, Jedrzej, Pula, Bartosz, Zamirska, Aleksandra, Bieniek, Andrzej, Szepietowski, Jacek C, Dziegiel, Piotr, Okolow, Marzenna Podhorska
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Carcinoma, Basal Cell - metabolism
Carcinoma, Squamous Cell - metabolism
Case-Control Studies
Female
Humans
Keratosis, Actinic - metabolism
Male
Middle Aged
Skin Neoplasms - metabolism
SOXF Transcription Factors - metabolism
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container_issue 5
container_start_page 2379
container_title Anticancer research
container_volume 36
creator Ornat, Maciej
Kobierzycki, Christopher
Grzegrzolka, Jedrzej
Pula, Bartosz
Zamirska, Aleksandra
Bieniek, Andrzej
Szepietowski, Jacek C
Dziegiel, Piotr
Okolow, Marzenna Podhorska
description SRY-related HMG box protein 18 (SOX18) is a transcription factor involved in a range of physiological processes, including differentiation of endothelial cells during new vessel formation. Numerous studies are being conducted to determine its role in carcinogenesis. Thirty-five cases of squamous cell carcinoma (SCC), 61 cases of basal cell carcinoma (BCC), 15 cases of actinic keratosis (AK) and 15 normal skin (NS) cases were examined in the study. Expression of SOX18 was investigated with immunohistochemistry and light optic microscopy. The obtained results were subjected to statistical analysis including available clinicopathological data. Nuclear expression of SOX18 was shown in vascular endothelial cells, basal layer cells of NS epidermis, as well as in AK, BCC and SCC cancer cells. Expression of SOX18 in SCC, BCC and AK cells was significantly higher than in NS (p
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Further studies with the use of additional markers tested at the mRNA and protein level are necessary for better explanation of SOX18 function in cancer transformation.</abstract><cop>Greece</cop><pmid>27127146</pmid></addata></record>
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subjects Adult
Aged
Aged, 80 and over
Carcinoma, Basal Cell - metabolism
Carcinoma, Squamous Cell - metabolism
Case-Control Studies
Female
Humans
Keratosis, Actinic - metabolism
Male
Middle Aged
Skin Neoplasms - metabolism
SOXF Transcription Factors - metabolism
title SOX18 Expression in Non-melanoma Skin Cancer
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