Organizing multivalency in carbohydrate recognition

The interactions of cell surface carbohydrates as well as of soluble glycoconjugates with their receptor proteins rule fundamental processes in cell biology. One of the supramolecular principles underlying and regulating carbohydrate recognition is multivalency. Many multivalent glycoconjugates have...

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Bibliographic Details
Published in:Chemical Society reviews 2016-06, Vol.45 (11), p.3275-332
Main Authors: Müller, Christian, Despras, Guillaume, Lindhorst, Thisbe K
Format: Article
Language:English
Subjects:
Animals
Biology
Carbohydrate Conformation
Carbohydrates
Carbohydrates - chemistry
Glycoconjugates - chemistry
Humans
Organizing
Proteins
Receptors
Recognition
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Summary:The interactions of cell surface carbohydrates as well as of soluble glycoconjugates with their receptor proteins rule fundamental processes in cell biology. One of the supramolecular principles underlying and regulating carbohydrate recognition is multivalency. Many multivalent glycoconjugates have therefore been synthesized to study multivalency effects operative in glycobiology. This review is focused on smaller multivalent structures such as glycoclusters emphasizing carbohydrate-centered and heteromultivalent glycoconjugates. We are discussing primary, secondary and tertiary structural aspects including approaches to organize multivalency. The interactions of carbohydrate ligands and their lectin receptors are fundamental processes in cell biology. They are ruled by various multivalency effects, which can be studied by synthetic glycoclusters based on primary, secondary and tertiary structural features.
ISSN:0306-0012
1460-4744
DOI:10.1039/c6cs00165c