Enzyme-responsive polyion complex (PIC) nanoparticles for the targeted delivery of antimicrobial polymers

Here we present new enzyme-responsive polyion complex (PIC) nanoparticles prepared from antimicrobial poly(ethylene imine) and an anionic enzyme-responsive peptide targeting Pseudomonas aeruginosa 's elastase. The synthetic conditions used to prepare these nanomaterials allowed us to optimise p...

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Bibliographic Details
Published in:Polymer chemistry 2016-04, Vol.7 (15), p.2684-269
Main Authors: Insua, Ignacio, Liamas, Evangelos, Zhang, Zhenyu, Peacock, Anna F. A, Krachler, Anne Marie, Fernandez-Trillo, Francisco
Format: Article
Language:English
Subjects:
Antiinfectives and antibacterials
Bacteria
Elastase
Enzymes
Nanoparticles
Peptides
Polymers
Pseudomonas aeruginosa
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Summary:Here we present new enzyme-responsive polyion complex (PIC) nanoparticles prepared from antimicrobial poly(ethylene imine) and an anionic enzyme-responsive peptide targeting Pseudomonas aeruginosa 's elastase. The synthetic conditions used to prepare these nanomaterials allowed us to optimise particle size and charge, and their stability under physiological conditions. We demonstrate that these enzyme responsive PIC nanoparticles are selectively degraded in the presence of P. aeruginosa elastase without being affected by other endogenous elastases. This enzyme-responsive PIC particle can exert an elastase-specific antimicrobial effect against P. aeruginosa without affecting non-pathogenic strains of these bacteria. These targeted enzyme-responsive PIC nanoparticles constitute a novel platform for the delivery of antimicrobial peptides and polymers, and can be a powerful tool in the current race against antimicrobial resistance. Here we present new enzyme-responsive polyion complex (PIC) nanoparticles prepared from antimicrobial poly(ethylene imine) and an anionic enzyme-responsive peptide targeting Pseudomonas aeruginosa 's elastase.
ISSN:1759-9954
1759-9962
DOI:10.1039/c6py00146g