Protein Kinase C Enzymes in the Hematopoietic and Immune Systems

The protein kinase C (PKC) family, discovered in the late 1970s, is composed of at least 10 serine threonine kinases, divided into three groups based on their molecular architecture and cofactor requirements. PKC enzymes have been conserved throughout evolution and are expressed in virtually all cel...

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Bibliographic Details
Published in:Annual review of immunology 2016-05, Vol.34 (1), p.511-538
Main Authors: Altman, Amnon, Kong, Kok-Fai
Format: Article
Language:English
Subjects:
Animals
Coenzymes - metabolism
Enzyme Activation - immunology
enzyme regulation
Hematopoiesis
Humans
Immune System
PKC
Protein Kinase C - immunology
Protein Kinase C - metabolism
Signal Transduction
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Summary:The protein kinase C (PKC) family, discovered in the late 1970s, is composed of at least 10 serine threonine kinases, divided into three groups based on their molecular architecture and cofactor requirements. PKC enzymes have been conserved throughout evolution and are expressed in virtually all cell types; they represent critical signal transducers regulating cell activation, differentiation, proliferation, death, and effector functions. PKC family members play important roles in a diverse array of hematopoietic and immune responses. This review covers the discovery and history of this enzyme family, discusses the roles of PKC enzymes in the development and effector functions of major hematopoietic and immune cell types, and points out gaps in our knowledge, which should ignite interest and further exploration, ultimately leading to better understanding of this enzyme family and, above all, its role in the many facets of the immune system.
ISSN:0732-0582
1545-3278
DOI:10.1146/annurev-immunol-041015-055347