Use of a platelet-rich fibrin membrane to repair traumatic tympanic membrane perforations: a comparative study

Objectives: (1) To evaluate the effects of a platelet-rich fibrin (PRF) membrane in the repair of traumatic tympanic membrane (TM) perforations; and (2) to compare the use of a PRF membrane with the paper patch technique with regard to recovery rates, healing time, and correction of the mean air-bon...

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Bibliographic Details
Published in:Acta oto-laryngologica 2016-10, Vol.136 (10), p.1017-1023
Main Authors: Gür, Özer Erdem, Ensari, Nuray, Öztürk, Mehmet Türker, Boztepe, Osman Fatih, Gün, Taylan, Selçuk, Ömer Tarık, Renda, Levent
Format: Article
Language:English
Subjects:
Adult
Audiometry
Blood Platelets
ear drum perforation
Female
Fibrin - therapeutic use
fibrin membrane
Humans
Male
Membranes, Artificial
Prospective Studies
thrombocyte concentrates
Tympanic Membrane Perforation - therapy
Wound healing
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Summary:Objectives: (1) To evaluate the effects of a platelet-rich fibrin (PRF) membrane in the repair of traumatic tympanic membrane (TM) perforations; and (2) to compare the use of a PRF membrane with the paper patch technique with regard to recovery rates, healing time, and correction of the mean air-bone gap. Methods: A randomized, prospective analysis was performed for 60 patients who were treated for traumatic TM perforations using one of the two methods. Closure rate, speed of healing, and hearing gain were compared between the PRF (Group 1) and paper patch (Group 2) groups. Results: Closure was obtained in 28 (93%) perforations in Group 1 and 25 (83%) perforations in Group 2 (p > 0.05). On day 10, full closure of the TM was observed in 24 (80%) patients in Group 1 and 16 (53%) patients in Group 2 (p 
ISSN:0001-6489
1651-2251
DOI:10.1080/00016489.2016.1183042