Breast Cancer Subtypes in Patients Aged 70 Years and Older

Recurrence and survival pattern in breast cancer (bc) patients (pts) ≥ 70 years subcategorized according to subtype and age are still an area of uncertainty. Tumor characteristics, patient demographics, therapies applied, and recurrence pattern were compared between luminal A (LA), luminal B (LB), H...

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Bibliographic Details
Published in:Cancer investigation 2016-05, Vol.34 (5), p.197-204
Main Authors: Königsberg, Robert, Pfeiler, Georg, Hammerschmid, Nicole, Holub, Oliver, Glössmann, Kerstin, Larcher-Senn, Julian, Dittrich, Christian
Format: Article
Language:English
Subjects:
adjuvant therapies
Age categories
Age Factors
Aged
Aged, 80 and over
Biomarkers, Tumor
breast cancer subtypes
Breast Neoplasms - diagnosis
Breast Neoplasms - mortality
Breast Neoplasms - therapy
Combined Modality Therapy
DDFS
Elderly patients
Female
Humans
Immunohistochemistry
LRFS
Neoplasm Grading
Neoplasm Metastasis
Neoplasm Recurrence, Local
Neoplasm Staging
Prognosis
Proportional Hazards Models
Retrospective Studies
Treatment Outcome
Tumor Burden
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Summary:Recurrence and survival pattern in breast cancer (bc) patients (pts) ≥ 70 years subcategorized according to subtype and age are still an area of uncertainty. Tumor characteristics, patient demographics, therapies applied, and recurrence pattern were compared between luminal A (LA), luminal B (LB), Her2/neu overexpressing (Her+) and triple-negative (TN) bc subtypes and the age subcategories 70-74, 75-79, ≥80 years. Based on univariate Cox-regression-analyses distant-disease-free-survival (DDFS) differed significantly for bc subtypes (p = 0.0002), notably for Her+ vs. LA (p = 0.0014), TN vs. LA (p < 0.001), and TN vs. LB (p = 0.0086). Not age, but Her+ and TN represented prognostic factors for DDFS.
ISSN:0735-7907
1532-4192
DOI:10.1080/07357907.2016.1182184