Breast Cancer Subtypes in Patients Aged 70 Years and Older

Recurrence and survival pattern in breast cancer (bc) patients (pts) ≥ 70 years subcategorized according to subtype and age are still an area of uncertainty. Tumor characteristics, patient demographics, therapies applied, and recurrence pattern were compared between luminal A (LA), luminal B (LB), H...

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Published in:Cancer investigation 2016-05, Vol.34 (5), p.197-204
Main Authors: Königsberg, Robert, Pfeiler, Georg, Hammerschmid, Nicole, Holub, Oliver, Glössmann, Kerstin, Larcher-Senn, Julian, Dittrich, Christian
Format: Article
Language:English
Subjects:
adjuvant therapies
Age categories
Age Factors
Aged
Aged, 80 and over
Biomarkers, Tumor
breast cancer subtypes
Breast Neoplasms - diagnosis
Breast Neoplasms - mortality
Breast Neoplasms - therapy
Combined Modality Therapy
DDFS
Elderly patients
Female
Humans
Immunohistochemistry
LRFS
Neoplasm Grading
Neoplasm Metastasis
Neoplasm Recurrence, Local
Neoplasm Staging
Prognosis
Proportional Hazards Models
Retrospective Studies
Treatment Outcome
Tumor Burden
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cited_by cdi_FETCH-LOGICAL-c366t-ba446be0a6e4349bedc95f30ef2ad742b2aaecc7bd54f716fe4a9d2a58df58913
cites cdi_FETCH-LOGICAL-c366t-ba446be0a6e4349bedc95f30ef2ad742b2aaecc7bd54f716fe4a9d2a58df58913
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container_title Cancer investigation
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creator Königsberg, Robert
Pfeiler, Georg
Hammerschmid, Nicole
Holub, Oliver
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Larcher-Senn, Julian
Dittrich, Christian
description Recurrence and survival pattern in breast cancer (bc) patients (pts) ≥ 70 years subcategorized according to subtype and age are still an area of uncertainty. Tumor characteristics, patient demographics, therapies applied, and recurrence pattern were compared between luminal A (LA), luminal B (LB), Her2/neu overexpressing (Her+) and triple-negative (TN) bc subtypes and the age subcategories 70-74, 75-79, ≥80 years. Based on univariate Cox-regression-analyses distant-disease-free-survival (DDFS) differed significantly for bc subtypes (p = 0.0002), notably for Her+ vs. LA (p = 0.0014), TN vs. LA (p < 0.001), and TN vs. LB (p = 0.0086). Not age, but Her+ and TN represented prognostic factors for DDFS.
doi_str_mv 10.1080/07357907.2016.1182184
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Tumor characteristics, patient demographics, therapies applied, and recurrence pattern were compared between luminal A (LA), luminal B (LB), Her2/neu overexpressing (Her+) and triple-negative (TN) bc subtypes and the age subcategories 70-74, 75-79, ≥80 years. Based on univariate Cox-regression-analyses distant-disease-free-survival (DDFS) differed significantly for bc subtypes (p = 0.0002), notably for Her+ vs. LA (p = 0.0014), TN vs. LA (p &lt; 0.001), and TN vs. LB (p = 0.0086). 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source Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list)
subjects adjuvant therapies
Age categories
Age Factors
Aged
Aged, 80 and over
Biomarkers, Tumor
breast cancer subtypes
Breast Neoplasms - diagnosis
Breast Neoplasms - mortality
Breast Neoplasms - therapy
Combined Modality Therapy
DDFS
Elderly patients
Female
Humans
Immunohistochemistry
LRFS
Neoplasm Grading
Neoplasm Metastasis
Neoplasm Recurrence, Local
Neoplasm Staging
Prognosis
Proportional Hazards Models
Retrospective Studies
Treatment Outcome
Tumor Burden
title Breast Cancer Subtypes in Patients Aged 70 Years and Older
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