A new dihydrofurocoumarin from the fruits of Pandanus tectorius Parkinson ex Du Roi

• Published in: Natural product research 2016-11, Vol.30 (21), p.2389-2395
• Main Authors: Nguyen, Tan Phat, Le, Tien Dung, Minh, Phan Nhat, Dat, Bui Trong, Pham, Nguyen Kim Tuyen, Do, Thi My Lien, Nguyen, Dinh Tuyen, Mai, Tri Dinh
• Format: Article
• Language: English
• Subjects: Coumarins - chemistry; Coumarins - isolation & purification; Coumarins - pharmacology; Fruit - chemistry; Glycoside Hydrolase Inhibitors - chemistry; Glycoside Hydrolase Inhibitors - isolation & purification; Glycoside Hydrolase Inhibitors - pharmacology; Pandanaceae - chemistry; Pandanus; Pandanus tectorius; pandanusin A; α-glucosidase inhibition
• ISSN: 1478-6419; 1478-6427
• DOI: 10.1080/14786419.2016.1188095

From the fruit of Pandanus tectorius Parkinson ex Du Roi, one new dihydrofurocoumarin, named pandanusin A (1) and 15 known compounds, including one furanocoumarin (2), two coumarins (3, 4), four lignans (5-8), one neolignan (9), two flavonoids (10, 11), three phenolics (12-14), one monoglyceride (15) and one monosaccharide (16) were isolated by various chromatography methods. Among them, compounds (3-5) were obtained from the Pandanus genus for the first time and compounds (9-14, 16) were reported from this species for the first time. Their structures were elucidated by HR-ESI-MS, NMR 1D and 2D experiments and comparison with previous reported data. The α-glucosidase inhibitory activity of all compounds was measured. The isolated compounds (1-12, 14) showed better α-glucosidase inhibitory activity (IC 50  = 42.2, 36.5, 84.7, 73.2, 40.8, 26.7, 76.5, 33.8, 68.1, 14.4, 22.1, 81.5, 43.8 μM, respectively) than the standard drug acarbose (IC 50  = 214.5 μM).