Immunohistochemical overexpression of hypoxia-induced factor 1α associated with slow reduction in 18 fluoro-2-deoxy-D-glucose uptake for chemoradiotherapy in patients with pharyngeal cancer

This study examined genomic factors associated with a reduction in fluoro-2-deoxy-D-glucose (FDG) uptake during positron emission tomography-computed tomography (PET-CT) for definitive chemoradiotherapy (CRT) in patients with pharyngeal cancer. The pretreatment and interim PET-CT images of 25 patien...

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Published in:European journal of nuclear medicine and molecular imaging 2016-12, Vol.43 (13), p.2343
Main Authors: Chen, Shang-Wen, Lin, Ying-Chun, Chen, Rui-Yun, Hsieh, Te-Chun, Yen, Kuo-Yang, Liang, Ji-An, Yang, Shih-Neng, Wang, Yao-Ching, Chen, Ya-Huey, Chow, Nan-Haw, Kao, Chia-Hung
Format: Article
Language:English
Subjects:
Adult
Aged
Biomarkers, Tumor - metabolism
Female
Fluorodeoxyglucose F18 - pharmacokinetics
Humans
Hypoxia-Inducible Factor 1, alpha Subunit - metabolism
Male
Metabolic Clearance Rate
Middle Aged
Neoplasm Staging
Pharyngeal Neoplasms - diagnostic imaging
Pharyngeal Neoplasms - metabolism
Pharyngeal Neoplasms - pathology
Positron Emission Tomography Computed Tomography - methods
Radiopharmaceuticals - pharmacokinetics
Reproducibility of Results
Sensitivity and Specificity
Up-Regulation
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Summary:This study examined genomic factors associated with a reduction in fluoro-2-deoxy-D-glucose (FDG) uptake during positron emission tomography-computed tomography (PET-CT) for definitive chemoradiotherapy (CRT) in patients with pharyngeal cancer. The pretreatment and interim PET-CT images of 25 patients with advanced pharyngeal cancers receiving definitive CRT were prospectively evaluated. The maximum standardized uptake value (SUV ) of the interim PET-CT and the reduction ratio of the SUV (SRR) between the two images were measured. Genomic data from pretreatment incisional biopsy specimens (SLC2A1, CAIX, VEGF, HIF1A, BCL2, Claudin-4, YAP1, MET, MKI67, and EGFR) were analyzed using tissue microarrays. Differences in FDG uptake and SRRs between tumors with low and high gene expression were examined using the Mann-Whitney test. Cox regression analysis was performed to examine the effects of variables on local control. The SRR of the primary tumors (SRR-P) was 0.59 ± 0.31, whereas the SRR of metastatic lymph nodes (SRR-N) was 0.54 ± 0.32. Overexpression of HIF1A was associated with a high iSUV of the primary tumor (P 
ISSN:1619-7089