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Immunohistochemical overexpression of hypoxia-induced factor 1α associated with slow reduction in 18 fluoro-2-deoxy-D-glucose uptake for chemoradiotherapy in patients with pharyngeal cancer
This study examined genomic factors associated with a reduction in fluoro-2-deoxy-D-glucose (FDG) uptake during positron emission tomography-computed tomography (PET-CT) for definitive chemoradiotherapy (CRT) in patients with pharyngeal cancer. The pretreatment and interim PET-CT images of 25 patien...
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| Published in: | European journal of nuclear medicine and molecular imaging 2016-12, Vol.43 (13), p.2343 |
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| container_title | European journal of nuclear medicine and molecular imaging |
| container_volume | 43 |
| creator | Chen, Shang-Wen Lin, Ying-Chun Chen, Rui-Yun Hsieh, Te-Chun Yen, Kuo-Yang Liang, Ji-An Yang, Shih-Neng Wang, Yao-Ching Chen, Ya-Huey Chow, Nan-Haw Kao, Chia-Hung |
| description | This study examined genomic factors associated with a reduction in
fluoro-2-deoxy-D-glucose (FDG) uptake during positron emission tomography-computed tomography (PET-CT) for definitive chemoradiotherapy (CRT) in patients with pharyngeal cancer.
The pretreatment and interim PET-CT images of 25 patients with advanced pharyngeal cancers receiving definitive CRT were prospectively evaluated. The maximum standardized uptake value (SUV
) of the interim PET-CT and the reduction ratio of the SUV
(SRR) between the two images were measured. Genomic data from pretreatment incisional biopsy specimens (SLC2A1, CAIX, VEGF, HIF1A, BCL2, Claudin-4, YAP1, MET, MKI67, and EGFR) were analyzed using tissue microarrays. Differences in FDG uptake and SRRs between tumors with low and high gene expression were examined using the Mann-Whitney test. Cox regression analysis was performed to examine the effects of variables on local control.
The SRR of the primary tumors (SRR-P) was 0.59 ± 0.31, whereas the SRR of metastatic lymph nodes (SRR-N) was 0.54 ± 0.32. Overexpression of HIF1A was associated with a high iSUV
of the primary tumor (P |
| format | article |
| fullrecord | <record><control><sourceid>pubmed</sourceid><recordid>TN_cdi_pubmed_primary_27311919</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>27311919</sourcerecordid><originalsourceid>FETCH-pubmed_primary_273119193</originalsourceid><addsrcrecordid>eNqFj0tOxDAQRC0kxAyfK6C-gKU4IzHJmo9gz37UOJ2xIXFbbptJjsUFOAJnIiNgzaqkVr3qqhO1Njem1duqaVfqXOS1qkxTN-2ZWtXbjTGtadfq82kcS2DnJbN1NHqLA_A7JZpiIhHPAbgHN0eePGofumKpgx5t5gTm6wNQhK3HvFwPPjuQgQ-QaPHlI-wDmAb6oXBiXeuOeJr1nd4PxbIQlJjxjaBfwo7vOWHnOTtKGOcjGzF7Cll-sqPDNIc9LR0tBkvpUp32OAhd_eqFun64f7591LG8jNTtYvLjguz-Bm_-NXwDYp1neA</addsrcrecordid><sourcetype>Index Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Immunohistochemical overexpression of hypoxia-induced factor 1α associated with slow reduction in 18 fluoro-2-deoxy-D-glucose uptake for chemoradiotherapy in patients with pharyngeal cancer</title><source>Springer Link</source><creator>Chen, Shang-Wen ; Lin, Ying-Chun ; Chen, Rui-Yun ; Hsieh, Te-Chun ; Yen, Kuo-Yang ; Liang, Ji-An ; Yang, Shih-Neng ; Wang, Yao-Ching ; Chen, Ya-Huey ; Chow, Nan-Haw ; Kao, Chia-Hung</creator><creatorcontrib>Chen, Shang-Wen ; Lin, Ying-Chun ; Chen, Rui-Yun ; Hsieh, Te-Chun ; Yen, Kuo-Yang ; Liang, Ji-An ; Yang, Shih-Neng ; Wang, Yao-Ching ; Chen, Ya-Huey ; Chow, Nan-Haw ; Kao, Chia-Hung</creatorcontrib><description>This study examined genomic factors associated with a reduction in
fluoro-2-deoxy-D-glucose (FDG) uptake during positron emission tomography-computed tomography (PET-CT) for definitive chemoradiotherapy (CRT) in patients with pharyngeal cancer.
The pretreatment and interim PET-CT images of 25 patients with advanced pharyngeal cancers receiving definitive CRT were prospectively evaluated. The maximum standardized uptake value (SUV
) of the interim PET-CT and the reduction ratio of the SUV
(SRR) between the two images were measured. Genomic data from pretreatment incisional biopsy specimens (SLC2A1, CAIX, VEGF, HIF1A, BCL2, Claudin-4, YAP1, MET, MKI67, and EGFR) were analyzed using tissue microarrays. Differences in FDG uptake and SRRs between tumors with low and high gene expression were examined using the Mann-Whitney test. Cox regression analysis was performed to examine the effects of variables on local control.
The SRR of the primary tumors (SRR-P) was 0.59 ± 0.31, whereas the SRR of metastatic lymph nodes (SRR-N) was 0.54 ± 0.32. Overexpression of HIF1A was associated with a high iSUV
of the primary tumor (P < 0.001) and neck lymph node (P = 0.04) and a low SRR-P (P = 0.02). Multivariate analysis revealed that patients who had tumors with low SRR-P or high HIF1A expression levels showed inferior local control.
In patients with pharyngeal cancer requiring CRT, HIF1A overexpression was positively associated with high interim SUV
or a slow reduction in FDG uptake. Prospective trials are needed to determine whether the local control rate can be stratified using the HIF1A level as a biomarker and SRR-P.</description><identifier>EISSN: 1619-7089</identifier><identifier>PMID: 27311919</identifier><language>eng</language><publisher>Germany</publisher><subject>Adult ; Aged ; Biomarkers, Tumor - metabolism ; Female ; Fluorodeoxyglucose F18 - pharmacokinetics ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit - metabolism ; Male ; Metabolic Clearance Rate ; Middle Aged ; Neoplasm Staging ; Pharyngeal Neoplasms - diagnostic imaging ; Pharyngeal Neoplasms - metabolism ; Pharyngeal Neoplasms - pathology ; Positron Emission Tomography Computed Tomography - methods ; Radiopharmaceuticals - pharmacokinetics ; Reproducibility of Results ; Sensitivity and Specificity ; Up-Regulation</subject><ispartof>European journal of nuclear medicine and molecular imaging, 2016-12, Vol.43 (13), p.2343</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27311919$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Shang-Wen</creatorcontrib><creatorcontrib>Lin, Ying-Chun</creatorcontrib><creatorcontrib>Chen, Rui-Yun</creatorcontrib><creatorcontrib>Hsieh, Te-Chun</creatorcontrib><creatorcontrib>Yen, Kuo-Yang</creatorcontrib><creatorcontrib>Liang, Ji-An</creatorcontrib><creatorcontrib>Yang, Shih-Neng</creatorcontrib><creatorcontrib>Wang, Yao-Ching</creatorcontrib><creatorcontrib>Chen, Ya-Huey</creatorcontrib><creatorcontrib>Chow, Nan-Haw</creatorcontrib><creatorcontrib>Kao, Chia-Hung</creatorcontrib><title>Immunohistochemical overexpression of hypoxia-induced factor 1α associated with slow reduction in 18 fluoro-2-deoxy-D-glucose uptake for chemoradiotherapy in patients with pharyngeal cancer</title><title>European journal of nuclear medicine and molecular imaging</title><addtitle>Eur J Nucl Med Mol Imaging</addtitle><description>This study examined genomic factors associated with a reduction in
fluoro-2-deoxy-D-glucose (FDG) uptake during positron emission tomography-computed tomography (PET-CT) for definitive chemoradiotherapy (CRT) in patients with pharyngeal cancer.
The pretreatment and interim PET-CT images of 25 patients with advanced pharyngeal cancers receiving definitive CRT were prospectively evaluated. The maximum standardized uptake value (SUV
) of the interim PET-CT and the reduction ratio of the SUV
(SRR) between the two images were measured. Genomic data from pretreatment incisional biopsy specimens (SLC2A1, CAIX, VEGF, HIF1A, BCL2, Claudin-4, YAP1, MET, MKI67, and EGFR) were analyzed using tissue microarrays. Differences in FDG uptake and SRRs between tumors with low and high gene expression were examined using the Mann-Whitney test. Cox regression analysis was performed to examine the effects of variables on local control.
The SRR of the primary tumors (SRR-P) was 0.59 ± 0.31, whereas the SRR of metastatic lymph nodes (SRR-N) was 0.54 ± 0.32. Overexpression of HIF1A was associated with a high iSUV
of the primary tumor (P < 0.001) and neck lymph node (P = 0.04) and a low SRR-P (P = 0.02). Multivariate analysis revealed that patients who had tumors with low SRR-P or high HIF1A expression levels showed inferior local control.
In patients with pharyngeal cancer requiring CRT, HIF1A overexpression was positively associated with high interim SUV
or a slow reduction in FDG uptake. Prospective trials are needed to determine whether the local control rate can be stratified using the HIF1A level as a biomarker and SRR-P.</description><subject>Adult</subject><subject>Aged</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Female</subject><subject>Fluorodeoxyglucose F18 - pharmacokinetics</subject><subject>Humans</subject><subject>Hypoxia-Inducible Factor 1, alpha Subunit - metabolism</subject><subject>Male</subject><subject>Metabolic Clearance Rate</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Pharyngeal Neoplasms - diagnostic imaging</subject><subject>Pharyngeal Neoplasms - metabolism</subject><subject>Pharyngeal Neoplasms - pathology</subject><subject>Positron Emission Tomography Computed Tomography - methods</subject><subject>Radiopharmaceuticals - pharmacokinetics</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><subject>Up-Regulation</subject><issn>1619-7089</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqFj0tOxDAQRC0kxAyfK6C-gKU4IzHJmo9gz37UOJ2xIXFbbptJjsUFOAJnIiNgzaqkVr3qqhO1Njem1duqaVfqXOS1qkxTN-2ZWtXbjTGtadfq82kcS2DnJbN1NHqLA_A7JZpiIhHPAbgHN0eePGofumKpgx5t5gTm6wNQhK3HvFwPPjuQgQ-QaPHlI-wDmAb6oXBiXeuOeJr1nd4PxbIQlJjxjaBfwo7vOWHnOTtKGOcjGzF7Cll-sqPDNIc9LR0tBkvpUp32OAhd_eqFun64f7591LG8jNTtYvLjguz-Bm_-NXwDYp1neA</recordid><startdate>201612</startdate><enddate>201612</enddate><creator>Chen, Shang-Wen</creator><creator>Lin, Ying-Chun</creator><creator>Chen, Rui-Yun</creator><creator>Hsieh, Te-Chun</creator><creator>Yen, Kuo-Yang</creator><creator>Liang, Ji-An</creator><creator>Yang, Shih-Neng</creator><creator>Wang, Yao-Ching</creator><creator>Chen, Ya-Huey</creator><creator>Chow, Nan-Haw</creator><creator>Kao, Chia-Hung</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>201612</creationdate><title>Immunohistochemical overexpression of hypoxia-induced factor 1α associated with slow reduction in 18 fluoro-2-deoxy-D-glucose uptake for chemoradiotherapy in patients with pharyngeal cancer</title><author>Chen, Shang-Wen ; Lin, Ying-Chun ; Chen, Rui-Yun ; Hsieh, Te-Chun ; Yen, Kuo-Yang ; Liang, Ji-An ; Yang, Shih-Neng ; Wang, Yao-Ching ; Chen, Ya-Huey ; Chow, Nan-Haw ; Kao, Chia-Hung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-pubmed_primary_273119193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Female</topic><topic>Fluorodeoxyglucose F18 - pharmacokinetics</topic><topic>Humans</topic><topic>Hypoxia-Inducible Factor 1, alpha Subunit - metabolism</topic><topic>Male</topic><topic>Metabolic Clearance Rate</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>Pharyngeal Neoplasms - diagnostic imaging</topic><topic>Pharyngeal Neoplasms - metabolism</topic><topic>Pharyngeal Neoplasms - pathology</topic><topic>Positron Emission Tomography Computed Tomography - methods</topic><topic>Radiopharmaceuticals - pharmacokinetics</topic><topic>Reproducibility of Results</topic><topic>Sensitivity and Specificity</topic><topic>Up-Regulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Shang-Wen</creatorcontrib><creatorcontrib>Lin, Ying-Chun</creatorcontrib><creatorcontrib>Chen, Rui-Yun</creatorcontrib><creatorcontrib>Hsieh, Te-Chun</creatorcontrib><creatorcontrib>Yen, Kuo-Yang</creatorcontrib><creatorcontrib>Liang, Ji-An</creatorcontrib><creatorcontrib>Yang, Shih-Neng</creatorcontrib><creatorcontrib>Wang, Yao-Ching</creatorcontrib><creatorcontrib>Chen, Ya-Huey</creatorcontrib><creatorcontrib>Chow, Nan-Haw</creatorcontrib><creatorcontrib>Kao, Chia-Hung</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>European journal of nuclear medicine and molecular imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Shang-Wen</au><au>Lin, Ying-Chun</au><au>Chen, Rui-Yun</au><au>Hsieh, Te-Chun</au><au>Yen, Kuo-Yang</au><au>Liang, Ji-An</au><au>Yang, Shih-Neng</au><au>Wang, Yao-Ching</au><au>Chen, Ya-Huey</au><au>Chow, Nan-Haw</au><au>Kao, Chia-Hung</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunohistochemical overexpression of hypoxia-induced factor 1α associated with slow reduction in 18 fluoro-2-deoxy-D-glucose uptake for chemoradiotherapy in patients with pharyngeal cancer</atitle><jtitle>European journal of nuclear medicine and molecular imaging</jtitle><addtitle>Eur J Nucl Med Mol Imaging</addtitle><date>2016-12</date><risdate>2016</risdate><volume>43</volume><issue>13</issue><spage>2343</spage><pages>2343-</pages><eissn>1619-7089</eissn><abstract>This study examined genomic factors associated with a reduction in
fluoro-2-deoxy-D-glucose (FDG) uptake during positron emission tomography-computed tomography (PET-CT) for definitive chemoradiotherapy (CRT) in patients with pharyngeal cancer.
The pretreatment and interim PET-CT images of 25 patients with advanced pharyngeal cancers receiving definitive CRT were prospectively evaluated. The maximum standardized uptake value (SUV
) of the interim PET-CT and the reduction ratio of the SUV
(SRR) between the two images were measured. Genomic data from pretreatment incisional biopsy specimens (SLC2A1, CAIX, VEGF, HIF1A, BCL2, Claudin-4, YAP1, MET, MKI67, and EGFR) were analyzed using tissue microarrays. Differences in FDG uptake and SRRs between tumors with low and high gene expression were examined using the Mann-Whitney test. Cox regression analysis was performed to examine the effects of variables on local control.
The SRR of the primary tumors (SRR-P) was 0.59 ± 0.31, whereas the SRR of metastatic lymph nodes (SRR-N) was 0.54 ± 0.32. Overexpression of HIF1A was associated with a high iSUV
of the primary tumor (P < 0.001) and neck lymph node (P = 0.04) and a low SRR-P (P = 0.02). Multivariate analysis revealed that patients who had tumors with low SRR-P or high HIF1A expression levels showed inferior local control.
In patients with pharyngeal cancer requiring CRT, HIF1A overexpression was positively associated with high interim SUV
or a slow reduction in FDG uptake. Prospective trials are needed to determine whether the local control rate can be stratified using the HIF1A level as a biomarker and SRR-P.</abstract><cop>Germany</cop><pmid>27311919</pmid></addata></record> |
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| ispartof | European journal of nuclear medicine and molecular imaging, 2016-12, Vol.43 (13), p.2343 |
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| subjects | Adult Aged Biomarkers, Tumor - metabolism Female Fluorodeoxyglucose F18 - pharmacokinetics Humans Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Male Metabolic Clearance Rate Middle Aged Neoplasm Staging Pharyngeal Neoplasms - diagnostic imaging Pharyngeal Neoplasms - metabolism Pharyngeal Neoplasms - pathology Positron Emission Tomography Computed Tomography - methods Radiopharmaceuticals - pharmacokinetics Reproducibility of Results Sensitivity and Specificity Up-Regulation |
| title | Immunohistochemical overexpression of hypoxia-induced factor 1α associated with slow reduction in 18 fluoro-2-deoxy-D-glucose uptake for chemoradiotherapy in patients with pharyngeal cancer |
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