Physico-chemical properties of fatty acids for assessing the threshold concentration to enhance the absorption of a hydrophilic substance

The effects of natural and non-natural fatty acids on enhancing the absorption of a hydrophilic marker through a human epithelial cell (Caco-2) monolayer were measured to elucidate the properties of the fatty acids. Fatty acids from C9 to C14 enhanced the absorption depending on the concentration an...

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Bibliographic Details
Published in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 1998, Vol.62 (3), p.443-447
Main Authors: Kimura, Y. (Kyoto Univ. (Japan)), Hosoda, Y, Shima, M, Adachi, S, Matsuno, R
Format: Article
Language:English
Subjects:
ABSORCION
ABSORPTION
absorption enhancement
ACIDE GRAS
ACIDOS GRASOS
Analytical, structural and metabolic biochemistry
Biological and medical sciences
Caco-2
CHEMICOPHYSICAL PROPERTIES
EXPERIMENTACION IN VITRO
EXPERIMENTATION IN VITRO
fatty acid
FATTY ACIDS
Feeding. Feeding behavior
Fundamental and applied biological sciences. Psychology
HIDROFOBICIDAD
HYDROPHOBICITE
HYDROPHOBICITY
IN VITRO EXPERIMENTATION
INTESTIN
INTESTINES
INTESTINOS
Lipids
Other biological molecules
physico-chemical property
PROPIEDADES FISICOQUIMICAS
PROPRIETE PHYSICOCHIMIQUE
Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Summary:The effects of natural and non-natural fatty acids on enhancing the absorption of a hydrophilic marker through a human epithelial cell (Caco-2) monolayer were measured to elucidate the properties of the fatty acids. Fatty acids from C9 to C14 enhanced the absorption depending on the concentration and the carbon chain length. Those fatty acids with longer chains gave a higher permeability coefficient at low concentrations and a lower toxicity than those with shorter chains. The surface energy lowering coefficient (SELC), an intrinsic physicochemical property, and the critical micellar concentration (CMC) were good criteria for identifying the threshold concentrations of a fatty acid to significantly enhance absorption
ISSN:0916-8451
1347-6947
DOI:10.1271/bbb.62.443