Prognostic Significance of NOGO-A/B and NOGO-B Receptor Expression in Malignant Melanoma - A Preliminary Study

Neurite outgrowth inhibitor type B (NOGO-B) and its receptor (NGBR) were shown to regulate various crucial cellular processes and may be therefore potential factors influencing carcinogenesis. Expression of NOGO-A, NOGO-A/B and NGBR was studied in benign melanocytic lesions and primary tumors and me...

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Published in:Anticancer research 2016-07, Vol.36 (7), p.3401
Main Authors: Calik, Jacek, Pula, Bartosz, Piotrowska, Aleksandra, Wojnar, Andrzej, Witkiewicz, Wojciech, Grzegrzolka, Jedrzej, Podhorska-Okolow, Marzena, Dziegiel, Piotr
Format: Article
Language:English
Subjects:
Adult
Aged
Biomarkers, Tumor - metabolism
Female
Humans
Immunohistochemistry
Male
Melanoma - metabolism
Melanoma - mortality
Melanoma - pathology
Middle Aged
Nogo Proteins - metabolism
Prognosis
Skin Neoplasms - metabolism
Skin Neoplasms - mortality
Skin Neoplasms - pathology
Survival Analysis
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Summary:Neurite outgrowth inhibitor type B (NOGO-B) and its receptor (NGBR) were shown to regulate various crucial cellular processes and may be therefore potential factors influencing carcinogenesis. Expression of NOGO-A, NOGO-A/B and NGBR was studied in benign melanocytic lesions and primary tumors and metastases of malignant melanoma (MM). Cytoplasmic expression of the studied antigens was detected in melanocytes and MM cells. NOGO-A/B expression was significantly lower in metastatatic MM cases compared to primary MM tumors (p
ISSN:1791-7530