Brainstem micro-abscesses caused by Burkholderia pseudomallei in a 10-month-old infant: a case report

Melioidosis is an uncommon tropical infectious disease caused by Burkholderia pseudomallei. Neurological complications of melioidosis are extremely uncommon in infants. A 10-month-old girl is described who presented with disseminated melioidosis with subcutaneous nodules, arthritis, hepatomegaly and...

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Bibliographic Details
Published in:Paediatrics and international child health 2017-07, Vol.37 (3), p.230-232
Main Authors: Prasanna Kumar, M., Krishnamurthy, Sriram, Venkateswaran, V. S., Mahadevan, Subramanian, Lalitha, M., Sistla, Sujatha, Nagarajan, K.
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - administration & dosage
Brain - diagnostic imaging
Brain Abscess - drug therapy
Brain Abscess - etiology
Brain Abscess - pathology
Brain Stem - pathology
Brainstem micro-abscesses
Burkholderia pseudomallei
Burkholderia pseudomallei - isolation & purification
Female
Humans
Infant
Magnetic Resonance Imaging
Melioidosis
Melioidosis - complications
Melioidosis - diagnosis
Melioidosis - drug therapy
Melioidosis - pathology
Neuromelioidosis
Thienamycins - administration & dosage
Treatment Outcome
Trimethoprim, Sulfamethoxazole Drug Combination - administration & dosage
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Description
Summary:Melioidosis is an uncommon tropical infectious disease caused by Burkholderia pseudomallei. Neurological complications of melioidosis are extremely uncommon in infants. A 10-month-old girl is described who presented with disseminated melioidosis with subcutaneous nodules, arthritis, hepatomegaly and a lung cavity, and developed a left medial rectus palsy. Cranial MRI demonstrated mid-brain, pontine and basal ganglia micro-abscesses. Therapy with meropenem and cotrimoxazole led to resolution of the medial nerve palsy. At 5-month follow-up, the child had no residual neurological deficits.
ISSN:2046-9047
2046-9055
DOI:10.1080/20469047.2016.1198560