Membrane activity of a supramolecular peptide-based chemotherapeutic enhancer

Self-assembly of de novo designed multidomain peptides (MDPs) resulted in functional membrane-active supramolecular nanofibers. The membrane activity was analyzed through fluorescence membrane localization and patch-clamp electrophysiology yielding important information that can be used for the deve...

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Bibliographic Details
Published in:Molecular bioSystems 2016-08, Vol.12 (9), p.2695-2699
Main Authors: Xu, Dawei, Jiang, Linhai, DeRidder, Louis, Elmore, Brendan, Bukhari, Maurish, Wei, Qiang, Samways, Damien S. K, Dong, He
Format: Article
Language:English
Subjects:
Antineoplastic Agents - pharmacology
Cell Membrane - chemistry
Cell Membrane - drug effects
Cell Membrane - metabolism
Cell Survival - drug effects
Cell-Penetrating Peptides - chemistry
Cell-Penetrating Peptides - pharmacology
Drug Synergism
Humans
Lipid Metabolism
Lipids - chemistry
Membrane Potentials - drug effects
Peptides - chemistry
Peptides - metabolism
Peptides - pharmacology
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Summary:Self-assembly of de novo designed multidomain peptides (MDPs) resulted in functional membrane-active supramolecular nanofibers. The membrane activity was analyzed through fluorescence membrane localization and patch-clamp electrophysiology yielding important information that can be used for the development of a new type of supramolecular peptide-based chemotherapeutic enhancer. This work explored the membrane activity of filamentous supramolecular peptides and their great potential as a supramolecular peptide-based chemotherapeutic enhancer.
ISSN:1742-206X
1742-2051
DOI:10.1039/c6mb00369a